Reflex responses in cardiac parasympathetic and sympathetic nerve activities during passive stretch or electrically-evoked contraction of skeletal muscle

骨骼肌被动拉伸或电诱发收缩期间心脏副交感神经和交感神经活动的反射反应

• 批准号: 12832029
• 负责人: MURATA Jun
• 金额: $ 2.3万
• 依托单位: HIROSHIMA UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2000
• 资助国家: 日本
• 起止时间: 2000 至 2001
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12832029/
• 关键词: cardiac vagal nerve activity; cardiac sympathetic nerve activity; heart rate; arterial blood pressure; muscle mechanoreflex; muscle metaboreflex; decerebrate cats; 反射性循環調節; 筋受容器; 筋収縮

We measured directly both cardiac vagal efferent nerve activity (CVNA) and cardiac sympathetic efferent nerve activity (CSNA) during passive stretch and static contraction of skeletal muscle in cats decerebrated at the level of the precollicular-premammillary body. CVNA gradually decreased during passive stretch of the hindlimb, which was sustained throughout the stretched during passive stretch of the hindlimb, which was sustained throughout the stretch. CSNA increased at the onset of passive stretch but this increase was not sustained. CVNA and CSNA responded differentially to the passive stretch of the triceps surae muscle as well as the hindlimb. The time course and direction of the cardiac autonomic responses to muscle stretch were not affected by partial sinoaortic denervation, although the magnitude of the CSNA response was augmented. On the other hand, CVNA was decreased during static muscle contraction evoked by electrical stimulation of the tibial nerve and CSNA was increased. These responses in CVNA and CSNA were augmented, as the muscle tension was increased. It is concluded that a reflex arising from skeletal muscle during passive stretch and static contraction contributes to differential regulation of cardiac parasympathetic and sympathetic efferent discharges.

我们直接测量了猫的心脏迷走神经传出神经活动（CVNA）和心脏交感神经传出神经活动（CSNA）在被动拉伸和静态收缩的骨骼肌在前丘-乳头体的水平去大脑。CVNA在后肢被动牵拉过程中逐渐下降，并在整个牵拉过程中持续。CSNA在被动牵张开始时增加，但这种增加并不持久。CVNA和CSNA对小腿三头肌和后肢的被动拉伸反应不同。的时间过程和方向的心脏自主神经反应的肌肉拉伸不受部分窦主动脉去神经，虽然CSNA反应的幅度增加。另一方面，CVNA在由电刺激胫神经引起的静态肌肉收缩期间减少，CSNA增加。随着肌张力的增加，CVNA和CSNA的这些反应增强。结论是被动牵张和静态收缩过程中骨骼肌产生的反射有助于心脏副交感神经和交感神经传出放电的差异调节。

项目成果

Murata J, Matsukawa K: "Cardiac vagal and sympathetic efferent discharges are differentially modified by stretch of skeletal muscle"American Journal of Physiology. 280. H237-H245 (2001)

Murata J、Matsukawa K：“骨骼肌的拉伸对心脏迷走神经和交感神经传出放电有不同的改变”美国生理学杂志。

Matsukawa, K: "Reflex responses in plasma catecholamines cansed by static contraction of skeletal muscle"The Japanese Journal of Physiology. 51・5. 591-597 (2001)

Matsukawa, K：“骨骼肌静态收缩引起的血浆儿茶酚胺的反射反应”，日本生理学杂志 51・5 (2001)。

Murata, J: "Response in cardiac autonomic nerve activity during spontaneous and electrically-evoked skeletal muscle contraction in decerebrate cats"The Japanese Journal of Physiology : Supplement. 50. S(65) (2000)

Murata, J：“去大脑猫自发和电诱发骨骼肌收缩过程中心脏自主神经活动的反应”《日本生理学杂志：增刊》。

Murata J, Matsukawa K, Komine H, Tsuchimochi H: "Baroreflex bradycardia is inhibited by central command during spontaneous skeletal muscle contraction"The Japanese Journal of Physiology. 51(Suppl). S141 (2001)

Murata J、Matsukawa K、Komine H、Tsuchimochi H：“在自发性骨骼肌收缩过程中，中枢命令会抑制压力反射性心动过缓”《日本生理学杂志》。

Matsukawa K: "Central control of the cardiovascular system during exercise"Exercise, Nutrition, and Environmental Stress Cooper Publishing Group. 39-64 (2000)

松川 K：“运动期间心血管系统的中央控制”运动、营养和环境压力库珀出版集团。