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Neural mechanisms of thermo-regulation : Identification of the cutaneous vasomotor center

温度调节的神经机制：皮肤血管舒缩中枢的识别

基本信息

批准号：
12670055
负责人：
TERUI Naohito
金额：
$ 2.18万
依托单位：
University of Tsukuba
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2000
资助国家：
日本
起止时间：
2000 至 2001
项目状态：
已结题

项目摘要

Neural mechanisms of thermo-regulation, especially the pathway from so called thermo-regulatory center of the hypothalamus to the cutaneous vasoconstrictor fibers has been poorly understood. The ear of the rabbit is one of the thermo-regulatory organ, controlling its blood flow. We previously proposed that the reticulo-spinal neurons (Cu neurons) in the rostral ventral medulla that excited by the electrical stimulation of the dorso-medial hypothalamus were premotor neurons for cutaneous vasoconstrictor fibers of the ear (Kishi, et al., 1999). In the present project, we simultaneously recorded activities of the ear sympathetic vasoconstrictor fibers and the reticulo-spinal neurons in the rostral ventral medulla and analyzed their spontaneous activity in the point of view of their rhythmic activities.Cu neurons and cutaneous vasoconstrictor fibers of the ear had not cardiac cycle-related rhythmic activity, but renal sympathetic nerve shown clear cardiac cycle-related rhythmic activity. Both Cu neurons and cutaneous vasoconstrictor fibers had respiration-related activity. The degree of modulation of the respiratory-related fluctuation of the activity of the Cu neuron was almost same as that of cutaneous vasoconstrictor fibers.The responsiveness to the stimulation of the dorso-medial hypothalamus and the spontaneous activity of the Cu neurons indicated that these Cu neurons were premotor neurons for the cutaneous vasoconstrictor fibers.

体温调节的神经机制，特别是从下丘脑的体温调节中心到皮肤血管收缩纤维的通路一直知之甚少。兔耳是体温调节器官之一，控制着其血液流动。我们先前提出，电刺激下丘脑背侧内侧的延髓吻侧腹侧的网状脊髓神经元(Cu神经元)是耳皮肤血管收缩纤维的运动前神经元(Kishi等，1999)。在本项目中，我们同时记录了耳交感血管收缩纤维和延髓嘴腹侧网状脊髓神经元的活动，并从节律活动的角度分析了它们的自发活动。耳部的铜神经元和皮肤血管收缩纤维没有心脏周期相关的节律活动，但肾交感神经具有明显的心脏周期相关的节律活动。铜神经元和皮肤血管收缩纤维均具有呼吸相关活动。铜神经元的呼吸相关活动波动的调制程度与皮肤血管收缩纤维基本相同，对刺激下丘脑背内侧的反应和铜神经元的自发活动表明，这些铜神经元是皮肤血管收缩纤维的运动前神经元。