Inputs to inhibitory neurons that mediate the baroreceptor reflex.

输入介导压力感受器反射的抑制性神经元。

• 批准号: 03670049
• 负责人: TERUI Naohito
• 金额: $ 1.28万
• 依托单位: Institute of Basic Medical Sciences, University of Tsukuba
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1991
• 资助国家: 日本
• 起止时间: 1991 至 1992
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-03670049/
• 关键词: Rostral ventrolateral medulla; Caudal ventrolateral medulla; Baroreceptor reflex; Somatosympathetic reflex; Glutamate; グルタメイト; 動脈圧受容器反射

In urethane-anesthetized rabbits, stimulation of the sural nerve, cutaneous afferents (A-fibers), evoked reflex responses consisting of an early small excitatory component followed by a prolonged inhibitory component in renal sympathetic nerve activity. Bilateral injections of GABA antagonist, bicuculline (4 nmol/site), into the rostral ventrolateral medulla (RVLM), where sympatho-excitatory reticulospinal neurons are located, attenuated the inhibitory component in a dose-dependent manner as well as the inhibition evoked by stimulation of the aortic nerve A-fibers (baroreceptor afferents). Bilateral injections of a neurotoxic agent, kainic acid (4 nmol/site, 3 sites/side),into the caudal ventrolateral medulla (CVLM), where sympatho-inhibitory neurons with axonal projection to the RVLM are located, diminished these sympatho-inhibitory responses. Therefore, it is concluded that the sympatho-inhibition evoked by activation of somatic afferents was mediated by neurons in the CVLM and by GABA receptors in the RVLM, as also was the sympatho-inhibition associated with the arterial baroreceptor reflex. Bilateral injections of kynurenic acid (4 nmol/site, 3 sites/side) into the CVLM did not affect the somatosympathetic reflex response, but diminished the sympatho-inhibition produced by activation of the baroreceptor afferents. Sympatho-inhibitory neurons in the CVLM were activated by glutamate when baroreceptor afferents were activated, but another excitatory transmitter may participate in the somato-sympathetic reflex in the CVLM.

在麻醉家兔中，刺激腓肠神经，皮肤传入（A-纤维），诱发反射反应，包括早期的小兴奋成分，随后是肾交感神经活动的长期抑制成分。双侧注射GABA拮抗剂荷包牡丹碱（4 nmol/部位），进入延髓腹外侧头端（RVLM），交感兴奋性网状脊髓神经元的位置，衰减的抑制成分，以剂量依赖性的方式，以及由主动脉神经A-纤维（压力感受器传入）的刺激引起的抑制。双侧注射的神经毒性剂，红藻氨酸（4纳摩尔/网站，3网站/侧），到尾侧腹外侧髓质（CVLM），其中的交感神经抑制神经元轴突投射到RVLM的位置，减少这些交感神经抑制反应。因此，可以得出结论，交感神经抑制诱发的激活躯体传入介导的神经元在CVLM和GABA受体在RVLM，也是交感神经抑制与动脉压力感受器反射。双侧注射犬尿烯酸（4 nmol/部位，3个部位/侧）到CVLM不影响躯体交感神经反射反应，但减少了由压力感受器传入的激活产生的交感神经抑制。当压力感受性传入被激活时，CVLM中的交感抑制神经元被谷氨酸激活，但另一种兴奋性递质可能参与CVLM中的躯体交感反射。

项目成果

106-114 (1992)

106-114（1992）

Kumada, M., Terui, N., Saeki, Y. and Kuwaki, T.: "Barosensitive neurons in the rostral and caudal ventrolateral medulla and their responses to activation of somatic afferent fibers" New Trends in Autonomic Nervous System Research Edts;Yoshikawa, M. et al,

Kumada, M.、Terui, N.、Saeki, Y. 和 Kuwaki, T.：“头端和尾端腹外侧延髓中的压力敏感神经元及其对体细胞传入纤维激活的反应”自主神经系统研究新趋势编辑；Yoshikawa

照井 直人: "自律神経反射ー動脈圧受容器反射を中心としてー" 日本臨牀. 50. 686-692 (1992)

Naoto Terui：“自主神经反射 - 关注动脉压力感受器反射”Nippon Rinsho。50. 686-692 (1992)。

MASUDA,N.and TERUI,N.: "Neurons in the caudal ventrolateral medulla mediate the somato-sympathetic inhibitory reflex response via GABA receptors in the rostral ventrolateral" J.Auton.Nerv.Syst.40. 91-98 (1992)

MASUDA,N. 和 TERUI,N.：“尾部腹外侧髓质中的神经元通过头侧腹外侧中的 GABA 受体介导躯体交感神经抑制反射反应”J.Auton.Nerv.Syst.40。

Masuda,N.and Terui,N.: "Neurons in the caudal ventrolateral medulla mediate the somato-sympathetic inhibitory reflex response via GABA receptors in the rostral ventrolateral medulla" J.Auton.Nerv.Syst.40. 91-98 (1992)

Masuda,N. 和 Terui,N.：“尾侧腹外侧髓质中的神经元通过头侧腹外侧髓质中的 GABA 受体介导躯体交感神经抑制反射反应”J.Auton.Nerv.Syst.40。