Localizaion of functionally different premortor neurons for the presympathetic neurons in the rostral ventrolateral medulla of rabbits.

兔延髓头端腹外侧交感神经元功能不同的前死神经元的定位。

• 批准号: 06680802
• 负责人: TERUI Naohito
• 金额: $ 1.41万
• 依托单位: University of Tsukuba
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1994
• 资助国家: 日本
• 起止时间: 1994 至 1995
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-06680802/
• 关键词: Rostral ventrolateral medulla; Blood flow; Sympathetic nerve; Rabbit; Vascularbed; Chemical stimulation; Locarization of premotor neurons; Locarization of presympathetic neurons; Blood pressure; Central grey

Whether the functionally different premotor neurons for the sympathetic preganglionic neurons are located in different area in the rostral ventrolateral medulla (RVLM) or not was studied in anesthetized and immobilized rabbits. Blood flow of muscles of a forelimb and a hind limb, kidney and skin of an ear was measured with laser or ultrasonic Doppler flow meters. Conductance of each vascular bed was calculated by the flow and the mean arterial pressure. Effects of micro-injection of neuroexcitatory or neuroinhibitory agents into the rostral ventrolateral medulla on conductance of vascular beds were investigated. The effective area for forelimb and hid limb muscle vascular conductance is localized in the caudal part of the RVLM,whereas for the kidney the effective area was located in the rostral part of the RVLM.Neurons thaht control the skin blood flow were located medial part of the RVLM.These effective areas, however, had a considerable overlap each other. Because the preganglionic neurons that innervate the vessels of the forelimb muscles are located at the same spinal segments of those innervate to vessels of the ear skin, we concluded that the premotor neurons for the sympathetic preganlionic neurons are located according to their function but not their axons projected.

在麻醉和制动的家兔上，观察了与交感节前神经元功能不同的运动前神经元是否位于延髓头端腹外侧区（RVLM）的不同区域。用激光或超声多普勒流量计测量前肢和后肢肌肉、肾脏和耳皮肤的血流量。根据血流和平均动脉压计算各血管床的电导。本文观察了延髓头端腹外侧区微量注射神经兴奋剂或神经抑制剂对血管床电导的影响。前肢和后肢肌肉血管传导的有效区位于RVLM的尾侧，而肾脏的有效区位于RVLM的吻侧，控制皮肤血流的神经元位于RVLM的内侧，但这些有效区之间有相当大的重叠。由于支配前肢肌肉血管的节前神经元与支配耳皮肤血管的节前神经元位于相同的脊髓节段，因此我们得出结论，交感节前神经元的运动前神经元根据其功能而不是其投射的轴突定位。

项目成果

Ootsuka, Y., Xu, T.and Terui, N.: "Localization of the presympathetic neurons of different cadiovascular function in the rostral ventrolateral medulla" J.J.Physiol. (in press). (1996)

Ootsuka, Y.、Xu, T. 和 Terui, N.：“不同心血管功能的交感前神经元在头端腹外侧延髓中的定位”J.J.Physiol。

Ootsuka, Y., Xu, T. and Terui, N.: "Acitivity of the 10 Hz rhythm in sympathetic nerves is mediated in the spinal cord." In : Central Nervous System and Blood Pressure Control. Eds : Niwa, M., Imaizumi, T. and Takahashi, H.49-57 (1994)

Ootsuka, Y.、Xu, T. 和 Terui, N.：“交感神经中 10 Hz 节律的活动是由脊髓介导的。”

照井直人: "心臓血管運動中枢としての延髄腹外側野" 中枢神経系と血管調節(高橋伯夫編). 23-37 (1995)

Naoto Terui：“延髓的腹外侧区作为心血管运动中心”中枢神经系统和血管调节（高桥白夫编辑）23-37（1995）。

Xu,T.,Ootsukua,Y.& Terui,N.: "The responses of the sympathetic nerve and blood pressure to chenical stimulation of the midbrain periaquedactal grey" J.J.Physiol.44. S71- (1994)

徐T.，大冢Y.

Kubota. A., Ootsuka, Y., Xu, T. and Terui, N.: "The 10-Hz rhythm in the sympathetic nerve acrtivity of cats, rats and rabbits." Neurosci. Lett.196. 173-176 (1995)

久保田。