A follow-up study on interactive effects of genetic factors and dietary habits on trends of blood pressure and bone mass among pregnant women

遗传因素与饮食习惯交互作用对孕妇血压和骨量变化趋势的追踪研究

• 批准号: 12670369
• 负责人: TAKASHIMA Yutaka
• 金额: $ 2.24万
• 依托单位: Kyorin University, School of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2000
• 资助国家: 日本
• 起止时间: 2000 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12670369/
• 关键词: Japanese women; Pregnancy; Angiotensinogen; Bone mass; Dietary habits; blood pressure; Follow-up study; Mitochodrial DNA; 妊婦; 遺伝情報; 骨密度; 栄養素; 骨代謝マーカー

In the present study project for three years between 2000 and 2002, we conducted three different studies. First, for seventy-six Japanese women who were assured of pregnancy between February 2000 and June 2000, subsequently experienced normal pregnancy and labor, and could be followed up until 6^<th> month after delivery at an obstetrics and gynecology clinic center located in Tokyo Metropolitan, the calcaneous bone mass was measured as osteo-assenssment index (OSI) using the quantitative ultrasound method. After the intra-individual changes in the OSI during the follow-up period were analyzed, the relations of the OSI or OSI change from gestation to postpartum to the estimates of nutrient and food intake obtained by a 140-item semi quantitative food-frequency questionnaire were analyzed using a stepwise multiple regression analysis. Secondly, for the same subjects involved in aforementioned first survey, associations of nutrients intake and / or angiotensinogen T174M genotype (AGTT174 … More M) with blood pressure or blood pressure changes during the investigation period were analyzed on the basis of blood pressure levels measured at first *osis of pregnancy, 36^<th> month of gestation and 1^<st> month after delivery. Thirdly, for middle and old-aged female residents in Mito-shi, Japan or *rrounding areas, several bio-marker levels relating to aging or atherosclerosis were compared between 'A' type and 'C" type of mitochondrial DNA 5178A/C polymorphism (Mt5178A/C) in order to investigate the potential roles of Mt5178A/C on health risks in Japanese women.Main results and conclusionsThe first study: Intake of iron, vitamin D, and fruits and vegetables during gestation and/or postpartum were positive correlates with the OSI change from gestational to postpartum, whereas it was inversely related to intake of carotene, sodium chloride and meats in gestation or postpartum. These results suggest that sufficient intake of iron, vitamin D, or fruits and vegetables may be important for preservation of bone mass after delivery.The second survey: Although blood pressure levels were all within normal range among subjects, mean blood pressure was slightly higher in M alle carriers than TT type in AGTT174M at all of the three investigation points. Blood pressure change during gestation was related significantly inversely to vitamin C intake and significantly positively to sodium chloride or calcium intake during gestation. Carrotene intake appeared to have beneficial effects on blood pressure among the pregnant women. The interactions of AGTT174M and dietary habits on blood pressure or blood pressure change were not clear.The third survey: It was found that serum triglycerides or albumin levels were significantly lower in A type (longevity type) than in C type (non-longevity type) of Mt5178A/C. Mt5178A/C might also be an important determinant of health risks in pregnant women. Less

在2000至2002年的三年研究项目中，我们进行了三项不同的研究。首先，在2000年2月至2000年6月期间，76名日本妇女在东京都的一家妇产科临床中心接受随访至产后6个月，她们随后经历了正常的妊娠和分娩，采用定量超声方法测量了跟骨骨量作为骨量指数(OSI)。在分析了随访期内OSI的个体内变化后，用逐步多元回归分析了孕期至产后OSI或OSI的变化与140项半定量食物频率问卷估计的营养和食物摄入量之间的关系。其次，对于上述第一次调查中涉及的同一受试者，营养素摄入量和/或血管紧张素原T174M基因(AGT174…)之间的关系对调查期内有血压或血压变化较多的M)，分别在孕初、孕36个月和产后1个月测得血压水平。第三，以日本及周边地区的中老年女性为对象，比较了线粒体DNA 5178A/C多态(Mt5178A/C)‘A’型和‘C’型与衰老或动脉粥样硬化相关的几个生物标志物水平，以探讨Mt5178A/C对日本女性健康风险的潜在作用。主要结果和结论研究一：孕期和产后铁、维生素D、水果和蔬菜的摄入量与孕期和产后的OSI变化呈正相关，而与孕期和产后胡萝卜素、氯化钠和肉类的摄入量呈负相关。这些结果表明，充足的铁、维生素D或水果和蔬菜的摄入对于产后骨量的保存可能很重要。第二项调查：尽管受试者的血压水平都在正常范围内，但在所有三个调查点，AGTT174M基因男性携带者的平均血压都略高于TT型。孕期血压变化与维生素C摄入量呈显著负相关，与孕期氯化钠或钙摄入量呈显著正相关。摄入胡萝卜素似乎对孕妇的血压有好处。AGTT174M与饮食习惯对血压或血压变化的交互作用尚不清楚。第三项调查：发现A型(长寿型)孕妇血清甘油三酯或白蛋白水平显著低于C型(非长寿型)。Mt5178A/C也可能是孕妇健康风险的重要决定因素。较少

项目成果

Takashima Y., Sumiya Y., Kokaze A., et al.: "Magnitude of the regression to the mean within one-year intraindividual changes in serum lipid levels among Japanese male workers"J Epidemiol. 11. 61-69 (2001)

Takashima Y.、Sumiya Y.、Kokaze A. 等人：“日本男性工人血脂水平一年内个体变化回归平均值的幅度”J Epidemiol。

Kokaze A, Ishikawa M, Matsunaga N, et al.: "Association of the mitochondrial DNA 5178 A/C polymorphism with serum lipid levels in the Japanese population"Hum Genet. 109. 521-525 (2001)

Kokaze A、Ishikawa M、Matsunaga N 等人：“日本人群中线粒体 DNA 5178 A/C 多态性与血清脂质水平的关联”Hum Genet。

Kokaze A, Ishikawa M, Matsunaga N, et al.: "Association of the longevity-associated mitochondrial DNA 5178 A/C polymorphism with serum protein fraction levels in healthy Japanese women"Exp Gerontology. 37. 931-936 (2002)

Kokaze A、Ishikawa M、Matsunaga N 等人：“健康日本女性长寿相关线粒体 DNA 5178 A/C 多态性与血清蛋白组分水平的关联”Exp Gerontology。

Kokaze A, Ishikawa M, Matsunaga N, et al.: "Association of the mitochondrial DNA5178A/C polymorphism with serum lipid levels in the Japanese population"Hum Genet. 109. 521-525 (2001)

Kokaze A、Ishikawa M、Matsunaga N 等人：“日本人群中线粒体 DNA5178A/C 多态性与血清脂质水平的关联”Hum Genet。

Kokaze, Matsunaga N., Yoshida M., et al.: "Geographic difference in genotype and alleic frequencies of insertion/deletion polymorphism of the angiotensin I converting enzyme gene in Japan"Jpn J Health & Human Ecology. 68. 19-24 (2002)

Kokaze、Matsunaga N.、Yoshida M.等人：“日本血管紧张素 I 转换酶基因的插入/缺失多态性的基因型和等位基因频率的地理差异”Jpn J Health