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Interactive Effects of Two Different Types of Single Nucleotide Polymorphism and Life Style on Intra-and Inter-individual Changes in Intraocular Pressure and Blood Pressure on the basis of the Longitudinal Epidemiological

基于纵向流行病学的两种不同类型的单核苷酸多态性与生活方式对个体内和个体间眼压和血压变化的交互影响

基本信息

批准号：
15390210
负责人：
TAKASHIMA Yutaka
金额：
$ 4.86万
依托单位：
Kyorin University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2003
资助国家：
日本
起止时间：
2003 至 2006
项目状态：
已结题

项目摘要

The objective of the present study was to clarify the interactive effects of various life style-related factors, angiotensinogen gene codon 174 (T174M) polymorphism (AGT174) and mitochondrial DNA 5178 A/C polymorphism (MT5178) on intra-and inter-individual changes in intraocular pressure and blood pressure on the basis of the epidemiological analyses. The subjects were middle and old-aged examinees of human dry dock conducted under the auspices of Mito Red Cross Hospital between 1999 and 2006. In addition to several cross-sectional studies, the follow-up studies were conducted in order to epidemiologically analyze the interrelations of the aforementioned genetic factors, life style, intraocular pressure (TOP) and blood pressure (BP).The following main results were obtained, revealing the interactive effects of the genetic factors and life style.1. The effects of drinking habit on diastolic blood pressure (DBP) differed between M allele carrier (MM/TM) and TT homozygote carrier (TT) in AGT174, showing clear inverse cross-sectional and longitudinal associations between drinking habit and DBP in MM/TM in contrast with positive associations in TT.2. From the longitudinal studies, it was found that time-related increases in DBP and IOP due to smoking habit, coffee intake habit and high BMI were more evident in MM/TM than in TT.3. A significant cross-sectional association between MT5178 and the effects of habitual drinking on blood pressure was found, showing that systolic and diastolic BP were significantly higher in daily drinkers than in occasional or non-drinkers among men carrying MT5178C, whereas no associations between drinking and BP were found in men carrying MT5178A.4. According to multiple regression analysis in the cross-sectional study, smoking habit was significantly associated with increased IOP in men with MT5178A, while drinking habit was significantly positively associated with IOP in those with MT5178C.

本研究的目的是在流行病学分析的基础上，阐明各种生活方式相关因素、血管紧张素原基因密码子174（T174 M）多态性（AGT 174）和线粒体DNA 5178 A/C多态性（MT5178）对眼压和血压个体内和个体间变化的交互作用。研究对象为1999年至2006年在水户红十字会医院主持下进行的人体干船坞检查的中老年受检者。本研究在多项横断面研究的基础上，对上述遗传因素与生活方式、眼内压（TOP）和血压（BP）的相互关系进行了流行病学的追踪研究，主要结果如下：1. AGT 174中M等位基因携带者（MM/TM）和TT纯合子携带者（TT）饮酒习惯对舒张压（DBP）的影响不同，MM/TM中饮酒习惯与DBP之间存在明显的横向和纵向负相关，而TT中饮酒习惯与DBP之间存在正相关。从纵向研究中发现，MM/TM中因吸烟习惯、咖啡摄入习惯和高BMI而导致的DBP和IOP的时间相关性增加比TT更明显。MT5178和习惯性饮酒对血压的影响之间存在显著的横截面相关性，表明在携带MT5178 C的男性中，每日饮酒者的收缩压和舒张压显著高于偶尔或不饮酒者，而在携带MT5178 A的男性中，饮酒和血压之间没有相关性。根据横断面研究中的多元回归分析，吸烟习惯与MT5178 A男性的IOP升高显著相关，而饮酒习惯与MT5178 C男性的IOP升高显著正相关。