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Study on surfactant-associated protein as a biomarker in the environmental pollutant exposure

表面活性剂相关蛋白作为环境污染物暴露生物标志物的研究

基本信息

批准号：
12670379
负责人：
MASAKI Kawami
金额：
$ 1.73万
依托单位：
The Institute for Science of Labour
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2000
资助国家：
日本
起止时间：
2000 至 2001
项目状态：
已结题

项目摘要

The purpose of this study was to investigate whether surfactant-associated proteins (SP-A, SP-D, KL-6) are serum biomarker of interstitial change with the mineral dust exposure and fibrosis progress. In addition, it was to investigate whether it evaluates surfactant-associated protein as serum biomarker in the environmental pollutant exposure. In pneumoconiosis patients, asbestosis patients who is the interstitial lung disease and dust exposure workers, we carried out the surfactant-associated proteins measurement with anti-neutrophils cytoplasm antibody (ANCA) and cytokines. And, the usefulness of the surfactant-associated proteins measurement were examined as a serum biomarker for evaluating the adverse effect to the health which accompanies the environmental pollutant exposure in the general inhabitants who lives in the neighbourhood of incineration facility.Idiopathic pulmonary fibrosis was seen to both of dust exposure workers and pneumoconiosis patients at the high rate. In these … More cases, that the increase in surfactant-associated protein level was observed indicated the relation with the occupational dust exposure. ANCA production and increase in the inflammatory cytokines were supposed that it activated neutrophils and that the inflammation of pulmonary tissue and blood vessel continues by the production of proteolytic enzymes and active oxygen, and that then, it may finally induce it to the development of the interstitial pneumonia.Therefore, the increase in surfactant-associated proteins was observed to pneumoconiosis patients and dust exposure workers, and it was indicated that it was useful as serum biomarker which reflects the process for the interstitial change with the occupational dust exposure. In the health survey in the inhabitants around the incinerator, on the usefulness as a serum biomarker for evaluating adverse effect to the health with the environmental pollutant exposure, it was not clear, and further examination would seem to be necessary in future. Less

本研究的目的是探讨表面活性物质相关蛋白（SP-A、SP-D、KL-6）是否是矿物粉尘暴露和纤维化过程中间质改变的血清生物标志物。此外，本研究还探讨了表面活性剂相关蛋白作为血清生物标志物在环境污染物暴露中的应用价值。采用抗中性粒细胞胞浆抗体（ANCA）和细胞因子对尘肺患者、石棉肺间质性肺病患者和接尘工人进行了表面活性物质相关蛋白的检测。同时，对生活在垃圾焚烧厂附近的普通居民进行了检测，以探讨表面活性物质相关蛋白作为评价环境污染物暴露对健康的不良影响的血清生物标志物的有效性。在这些 ...更多信息结果表明，粉尘工人血清中表面活性物质相关蛋白水平升高，与职业接尘有关。ANCA的产生和炎性细胞因子的增加，推测其激活中性粒细胞，通过蛋白水解酶和活性氧的产生，使肺组织和血管的炎症持续，最终可能诱发间质性肺炎的发展，因此，在尘肺患者和接尘工人中观察到表面活性物质相关蛋白的增加，提示其可作为反映职业性接尘间质变化过程的血清生物标志物。在焚烧炉周围居民的健康调查中，作为血清生物标志物评估环境污染物暴露对健康的不利影响的有用性尚不清楚，未来似乎有必要进一步研究。少