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Roles of oxidative stresses in neurodegeneration and myodegeneration focusing on the heme catabolism

Roles of oxidative stresses in neurodegeneration and myodegeneration focusing on the heme catabolism
氧化应激在神经变性和肌变性中的作用，重点关注血红素分解代谢
批准号：
12670588
负责人：
TAKEDA Atsushi
金额：
$1.98万
依托单位：
Tohoku University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2000
资助国家：
日本
项目状态：
已结题
起止时间：
2000 至 2002
来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12670588/
关键词：
oxidative stressesRNA oxidationnucleic acid oxidationAlzheimer diseaseParkinson diseasemultiple system atrophyheme oxygenaseParkinson diseaseAlzheimer diseasebilirubinbiopyrrinalpha-synucleinoxidative stressneurodege

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中文摘要
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英文摘要
Through this project, we revealed that increased levels of RNA oxidation were commonly observed in brains affected with neurodegenerative diseases including Alzheimer disease, Parkinson disease and dementia with Lewy bodies. The oxidized RNAs were prominently identified in the affected brain lesions in their early stages, and were decreased wish the progression of diseases. Furthermore, the end product of RNA oxidation, 8-hydroxy guanosine (8OHG), was increased in the serum and CSF samples of Parkinson disease and multiple system atrophies. It is suggested that the levels of 8OHG can be applied for the diagnostic biomarker of neurodegenerative diseases.We also identified that the RNA oxidation was associated wish the degenerative changes in smyopathies wish rimmed vacuoles. Through our investigation, it was shown that oxidative stresses might play a key roles in myodegeneration.
期刊论文(33)
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会议论文
Kikuchi A., et al.: "Hypoperfusion in the supplementary motor area, dorsolateral prefrontal cortex and insular cortex in Parkinson's disease"Journal of Neurologial Science. 193. 29-36 (2001)
Kikuchi A. 等人：“帕金森病中辅助运动区、背外侧前额皮质和岛叶皮质的灌注不足”《神经科学杂志》。
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通讯作者：
Nunomura A., Chiba A., Kosaka K., Takeda A., Castellani RJ., Smith MA., Perry G: "Neuronal RNA oxidation is a prominent feature of dementia with Lewy bodies."Neuro Report. 13. 2035-2039 (2002)
Nunomura A.、Chiba A.、Kosaka K.、Takeda A.、Castellani RJ.、Smith MA.、Perry G：“神经元 RNA 氧化是路易体痴呆的一个突出特征。”《神经报告》。
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通讯作者：
Castellani RJ., Hirai K., Aliev G., Drew KL., Nunomura A., Takeda A., Cashi AD., Obrenovich ME., Perry G., Smith MA.: "Role of mitachondrial dysfunction in Alzheimer disease."J. Neuroscience Research. 70. 357-360 (2002)
Castellani RJ.、Hirai K.、Aliev G.、Drew KL.、Nunomura A.、Takeda A.、Cashi AD.、Obrenovich ME.、Perry G.、Smith MA.：“线粒体功能障碍在阿尔茨海默病中的作用。”
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Perry G., Nunomura A., Hirai K., Zhu X., Perz M., Avila J., Castellani RJ., Atwood CS., Aliev G., Sayre LM., Takeda A., Smith MA.: "Is oxidative damage the fundamental pathogenic mechanism of Alzheimer's and other neurodegenerative diseases?"Free Radical
Perry G.、Nunomura A.、Hirai K.、Zhu X.、Perz M.、Avila J.、Castellani RJ.、Atwood CS.、Aliev G.、Sayre LM.、Takeda A.、Smith MA.：“是
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共 33 条
    Improvement of a liquid xenon detector for low threshold and high accuracy and search for anual modulation signals caused by dark matter particle using the detector
    • 批准号：
      25800132
    • 项目类别：
      Grant-in-Aid for Young Scientists (B)
    • 资助金额：
      $1.83万
    • 财政年份：
      2013
    • 负责人：
      TAKEDA Atsushi
    • 依托单位：
      The University of Tokyo
    Establishment of an efficient TALE-mediated genome editing in plants
    micro RNA as a novel biomarker for neurodegenerative diseses
    • 批准号：
      24659423
    • 项目类别：
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额：
      $2.33万
    • 财政年份：
      2012
    • 负责人：
      TAKEDA Atsushi
    • 依托单位：
      Tohoku University
    Waon: A Flexible Structured P2P Network
    • 批准号：
      23650032
    • 项目类别：
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额：
      $2.25万
    • 财政年份：
      2011
    • 负责人：
      TAKEDA Atsushi
    • 依托单位：
      Tohoku Gakuin University
    海外基金