Role of Essential Trace Metals in brain

必需微量金属在大脑中的作用

基本信息

  • 批准号:
    07672369
  • 负责人:
  • 金额:
    $ 0.32万
  • 依托单位:
  • 依托单位国家:
    日本
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 财政年份:
    1995
  • 资助国家:
    日本
  • 起止时间:
    1995 至 1996
  • 项目状态:
    已结题

项目摘要

The brains of rats injected intravenously with ^<65>ZnCl_2 or ^<54>MnC_2 were subjected to high-resolution autoradiography. The distribution of ^<65>Zn and ^<54>Mn in each brain region gradually decreased from 6 days to 42 days for ^<65>Zn and form 15 days to 60 days for 54 Mn after the injection. The biological half-lives of Zn in each region studied were in the range of 16-43 days ; the longest was observed in the amygdaloid nuclei. The regions where the long biological half-life was observed were consistent with the ones with the high density of Zn-containing neuton terminals reported previously. The biological half-lives of Mn in each region determined were 51-74 days ; the longest were those in the hypothalamic nuclei and thalamus.To study zinc (Zn) mobility in the rat olfactory tract, brain distribution of ^<65>Zn after injection into the olfactory bulb or amygdaloid nuclei was analyzed by autoradiography. Twenty-four h after ^<65>Zn injection into the olfactory bulb, ^<65>Zn was … More distributed in the ipsilateral piriform cortex, amygdaloid nuclei and the anterior commissure. Moreover, in the case of injection of a higher level of ^<65>Zn into the olfactory bulb, ^<65>Zn was distributed in the ipsilateral entorhinal cortex in addition to the above regions. Twenty-four h after ^<65>Zn injecjtion into the amygdaloid nuclei, ^<65>Zn was distributed in the ipsilateral piriform and entorhinal cortex. These results suggest that Zn is intraneuronally transported along the olfactory tract. Zn may be taken up by the piriform neurons after release from the secondary olfactory neuron terminals and transported to the entorhinal area.^<65>Zn was injected into the striatum or substantia nigra of rats to see the mobility of intracerebral Zn. In the case of intrastriatal injection, ^<65>Zn was densely distributed in the medial forebrain bundle (MFB) and substantia nigra. In the case of intranigral injection, ^<65>Zn was densely distributed in the MFB and also in the striatum and globus pallidus. On unilateral colchicine injection into the MFB,^<65>Zn distribution in the ipsilateral substantia nigra decreased significantly compared to that of the contralateral one after ^<65>Zn injection into the striatum. These results suggest the presence of axonal transport of Zn in pathway of g-amino butyric acid (GABA)-ergic striato-nigra fibers. Moreover, the ^<65>Zn distribution data 1 day after both injections indicated that its distributed regions were those with the GABAergic systems. Less
对大鼠脑内静脉注射^<65>ZnCl_2或^<54>MnC_2进行高分辨率放射自显影。^<65>Zn和^<54>Mn在脑各区域的分布逐渐减少,注射^<65>Zn后6天至42天,注射54 Mn后15天至60天。各地区Zn的生物半衰期在16 ~ 43 d之间;最长的是杏仁核。观察到的长生物半衰期区域与先前报道的含锌中子终端密度高的区域一致。各地区Mn的生物半衰期为51 ~ 74 d;最长的是下丘脑核和丘脑。为研究锌在大鼠嗅道内的流动性,采用放射自显影法分析了大鼠嗅球或杏仁核注射锌后脑内的分布。在嗅球注射^<65>Zn 24 h后,^<65>Zn在同侧梨状皮质、杏仁核和前联合中分布较多。此外,当向嗅球注射较高水平的^<65>Zn时,^<65>Zn除了分布在上述区域外,还分布在同侧嗅内皮层。杏仁核内注射^<65>Zn 24 h后,^<65>Zn分布于同侧梨状皮质和内嗅皮质。这些结果表明锌是沿嗅觉束在神经内运输的。锌从次级嗅觉神经元末梢释放后,可能被梨状神经元吸收并转运到嗅内区。^在大鼠纹状体或黑质注射Zn,观察脑内Zn的活动性。在纹状体内注射时,^<65>Zn密集分布于内侧前脑束(MFB)和黑质。在黑质内注射的情况下,^<65>Zn密集分布于MFB以及纹状体和苍白球。单侧注射秋水仙碱后,纹状体注射^<65>Zn后,同侧黑质中^<65>Zn的分布明显低于对侧黑质。这些结果表明锌在g-氨基丁酸(GABA)-能纹状体-黑质纤维通路中存在轴突转运。此外,两次注射后1天的^<65>Zn分布数据表明,其分布区域为gaba能系统。少

项目成果

期刊论文数量(6)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Atsushi Takeda, Shioji Ishiwatari, Jinko Sawashita, Yuka Kodama and Shoji Okada: "Manganese transport in blood-cerebrospinal fluid barrier and its intracerebral transport." Jpn.J.Toxicol.Environ.Health. 43. 28 (1997)
Atsushi Takeda、Shioji Ishiwatari、Jinko Sawashita、Yuka Kodama 和 Shoji Okada:“血脑脊液屏障中的锰转运及其脑内转运。”
  • DOI:
  • 发表时间:
  • 期刊:
  • 影响因子:
    0
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  • 通讯作者:
Atsushi Takeda et al.: "Manganese transport in blood-cerebrospinal fluid barrier and its inracerebral transport" Jpn. J. Toxicol. Environ. Health(衛生化学). 43. 28- (1997)
Atsushi Takeda 等人:“血脑脊液屏障中的锰转运及其脑内转运”J. Toxicol Health。 43. 28- (1997)
  • DOI:
  • 发表时间:
  • 期刊:
  • 影响因子:
    0
  • 作者:
  • 通讯作者:
Atsushi Takeda, Jinko Sawashita and Shoji Okada: "Brain uptake of the trace metals, zinc and manganese, in rats." Jpn.J.Toxicol.Environ.Health. 41. 49 (1995)
Atsushi Takeda、Jinko Sawashita 和 Shoji Okada:“大鼠大脑对微量金属锌和锰的吸收。”
  • DOI:
  • 发表时间:
  • 期刊:
  • 影响因子:
    0
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  • 通讯作者:
加治正行 他: "当院における妊婦・新生児の血清および母乳中の亜鉛・銅濃度に関する検討" Biomed. Res. Trace Elements. 7. 187-188 (1996)
Masayuki Kaji 等人:“我们医院孕妇和新生儿血清和母乳中锌和铜浓度的研究”,微量元素研究,7. 187-188 (1996)。
  • DOI:
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  • 影响因子:
    0
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武田厚司,他: "ラットの線条体に亜鉛及びマンガンを投与した場合の脳内動態" Biomed.Res.Trace Elements. 6. 157-158 (1995)
Atsushi Takeda 等人:“向大鼠纹状体施用锌和锰时的脑动力学”Biomed.Res.Trace Elements。
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    0
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TAKEDA Atsushi其他文献

Doctoral Students in the American Research Universities: the Difference by Major Field: An Analysis of the Doctoral Student Survey 2006 by the National Research Council
美国研究型大学的博士生:专业领域差异:国家研究委员会2006年博士生调查分析
  • DOI:
    10.1109/iiai-aai.2018.00094
  • 发表时间:
    2018
  • 期刊:
  • 影响因子:
    0
  • 作者:
    SUZUKI Toru;TAKEDA Atsushi;TAKADAYA Yoko;FUJII Yoshihiro;Kenji MIWA;Soichiro Aihara
  • 通讯作者:
    Soichiro Aihara
A Study about the Instruction for Master Thesis and Research Papers for "Experience Reflection" in Graduate Schools in Japan
日本研究生院硕士论文和研究论文“经验反思”指导研究
学校規模ポジティブ行動支援(SWPBS)が公立中学校における問題行動発生率に及ぼす効果 ―4年間にわたる実行度の変化と問題行動発生率の推移―
全校积极行为支持(SWPBS)对公立初中问题行为发生率的影响 -4年来实施水平的变化和问题行为发生率的变化-
  • DOI:
  • 发表时间:
    2023
  • 期刊:
  • 影响因子:
    0
  • 作者:
    SUZUKI Toru;FUJII Yoshihiro;MAEBARA Kazuaki;TAKEDA Atsushi;谷川雄一・庭山和貴
  • 通讯作者:
    谷川雄一・庭山和貴
IL-17A deficiency leads to attenuated neutrophilic inflammation and promoted wound healing in skin
IL-17A 缺乏导致中性粒细胞炎症减弱并促进皮肤伤口愈合
  • DOI:
  • 发表时间:
    2014
  • 期刊:
  • 影响因子:
    0
  • 作者:
    TAKAGI Naoyuki;KANNO Emi;TANNO Hisomasa;TAKEDA Atsushi;ISHII Keiko;IWAKURA Yoichiro;KAWAKAMI Kazuyoshi
  • 通讯作者:
    KAWAKAMI Kazuyoshi
A case of retention cyst of the parotid gland treated successfully by intraoral marsupialization
口内造袋术成功治疗腮腺潴留性囊肿一例

TAKEDA Atsushi的其他文献

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{{ truncateString('TAKEDA Atsushi', 18)}}的其他基金

Improvement of a liquid xenon detector for low threshold and high accuracy and search for anual modulation signals caused by dark matter particle using the detector
低阈值高精度液态氙探测器的改进及利用该探测器搜索暗物质粒子引起的模拟调制信号
  • 批准号:
    25800132
  • 财政年份:
    2013
  • 资助金额:
    $ 0.32万
  • 项目类别:
    Grant-in-Aid for Young Scientists (B)
Establishment of an efficient TALE-mediated genome editing in plants
建立有效的 TALE 介导的植物基因组编辑
  • 批准号:
    24658283
  • 财政年份:
    2012
  • 资助金额:
    $ 0.32万
  • 项目类别:
    Grant-in-Aid for Challenging Exploratory Research
micro RNA as a novel biomarker for neurodegenerative diseses
微小RNA作为神经退行性疾病的新型生物标志物
  • 批准号:
    24659423
  • 财政年份:
    2012
  • 资助金额:
    $ 0.32万
  • 项目类别:
    Grant-in-Aid for Challenging Exploratory Research
Waon: A Flexible Structured P2P Network
Waon:灵活的结构化 P2P 网络
  • 批准号:
    23650032
  • 财政年份:
    2011
  • 资助金额:
    $ 0.32万
  • 项目类别:
    Grant-in-Aid for Challenging Exploratory Research
Development of a novel system of the gene therapy for peripheral arterial diseases.
开发外周动脉疾病基因治疗的新系统。
  • 批准号:
    23592638
  • 财政年份:
    2011
  • 资助金额:
    $ 0.32万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Modulation and Impairment of learning and memory by hippocampal zinc
海马锌对学习和记忆的调节和损害
  • 批准号:
    22390025
  • 财政年份:
    2010
  • 资助金额:
    $ 0.32万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Analysis of the mechanisms of plant viral RNA silencing suppressors
植物病毒RNA沉默抑制子的作用机制分析
  • 批准号:
    22780035
  • 财政年份:
    2010
  • 资助金额:
    $ 0.32万
  • 项目类别:
    Grant-in-Aid for Young Scientists (B)
Development of 3-dimensional position calibration system for dark matter search detector
暗物质搜索探测器三维位置标定系统的研制
  • 批准号:
    22740144
  • 财政年份:
    2010
  • 资助金额:
    $ 0.32万
  • 项目类别:
    Grant-in-Aid for Young Scientists (B)
Secure and Scalable P2P Network with Usability and Anonymity
安全、可扩展的 P2P 网络,具有可用性和匿名性
  • 批准号:
    20700069
  • 财政年份:
    2008
  • 资助金额:
    $ 0.32万
  • 项目类别:
    Grant-in-Aid for Young Scientists (B)
Molecular mechanisms of cell death in synucleinopathy
突触核蛋白病细胞死亡的分子机制
  • 批准号:
    19590978
  • 财政年份:
    2007
  • 资助金额:
    $ 0.32万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)

相似海外基金

Elucidating the role of manganese in brain physiology and disease
阐明锰在脑生理和疾病中的作用
  • 批准号:
    MR/V006754/1
  • 财政年份:
    2021
  • 资助金额:
    $ 0.32万
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    Fellowship
Mechanisms of Brain Manganese Homeostasis and Manganese-induced Parkinsonism
脑锰稳态和锰诱发帕金森病的机制
  • 批准号:
    10318895
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    2021
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    $ 0.32万
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Regional Brain Manganese Accumulation and Functional Consequences in Welders
焊工脑部区域锰积累及其功能后果
  • 批准号:
    8663697
  • 财政年份:
    2011
  • 资助金额:
    $ 0.32万
  • 项目类别:
Regional Brain Manganese Accumulation and Functional Consequences in Welders
焊工脑部区域锰积累及其功能后果
  • 批准号:
    8185903
  • 财政年份:
    2011
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    $ 0.32万
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Regional Brain Manganese Accumulation and Functional Consequences in Welders
焊工脑部区域锰积累及其功能后果
  • 批准号:
    8320855
  • 财政年份:
    2011
  • 资助金额:
    $ 0.32万
  • 项目类别:
Regional Brain Manganese Accumulation and Functional Consequences in Welders
焊工脑部区域锰积累及其功能后果
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    8463536
  • 财政年份:
    2011
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    $ 0.32万
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Brain Manganese Deposition in High Risk Neonates
高危新生儿脑锰沉积
  • 批准号:
    7103345
  • 财政年份:
    2006
  • 资助金额:
    $ 0.32万
  • 项目类别:
Brain Manganese Deposition in High Risk Neonates
高危新生儿脑锰沉积
  • 批准号:
    7244111
  • 财政年份:
    2006
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    $ 0.32万
  • 项目类别:
BRAIN MANGANESE DEPOSITION IN HIGH RISK NEONATES
高危新生儿脑锰沉积
  • 批准号:
    7731399
  • 财政年份:
    2006
  • 资助金额:
    $ 0.32万
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BRAIN MANGANESE DEPOSITION IN HIGH RISK NEONATES
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    7605574
  • 财政年份:
    2006
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    $ 0.32万
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