Modulation and Impairment of learning and memory by hippocampal zinc
Modulation and Impairment of learning and memory by hippocampal zinc
批准号:
22390025
负责人:
TAKEDA Atsushi
金额:
$10.57万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012
中文摘要
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英文摘要
Glutamatergic (zincergic) neurons are concentrated in the hippocampus, where Zn2+plays an important role in memory acquisition. The accepted mechanisms of memory are synaptic plasticity. Long-term potentiation (LTP) is known as a cellular model of synaptic plasticity. Zn2+multi-functionally modulates LTP induction in the hippocampus and is involved in memory acquisition . However,dyshomeostasis of synaptic Zn2+in the hippocampus, which is induced by stress, is involved in the impairment of memory. The present study demonstrated that synaptic Zn2+participates in acquisition and impairment of memory .
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Dynamic action of neurometals at the synapse.
神经金属在突触的动态作用。
DOI:
--
发表时间:
2011
期刊:
Metallomics
影响因子:
3.4
作者:
[五味宏樹, 他, M.Tanaka, Haruna Tamano and Atsushi Takeda]
通讯作者:
Haruna Tamano and Atsushi Takeda
Atsushi Takeda, Shunsuke Takada, Masatoshi Nakamura, Miki Suzuki, Haruna Tamano, Masaki Ando, and Naoto Oku
武田敦、高田俊介、中村正敏、铃木美纪、玉野春菜、安藤正树和奥直人
DOI:
--
发表时间:
2011
期刊:
PLoS One
影响因子:
3.7
作者:
[Atsushi Takeda, Shunsuke Takada, Masatoshi Nakamura, Miki Suzuki, Haruna Tamano, Masaki Ando, and Naoto Oku]
通讯作者:
and Naoto Oku
Involvement of NMDA receptor subunits in zinc-mediated modification of CA1 LTP in the developing hippocampus
NMDA 受体亚基参与发育中海马 CA1 LTP 锌介导的修饰
DOI:
10.1002/jnr.22787
发表时间:
2012
期刊:
J.Neurosci.Res.
影响因子:
--
作者:
[Atsushi Takeda, et al]
通讯作者:
et al
ニューロジンクの動態解析と脳機能制御
神经锌动态分析与脑功能控制
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Katsu, K., Yokouchi, Y., 武田厚司]
通讯作者:
武田厚司
DOI:
10.1016/j.neuint.2010.07.010
发表时间:
2010-11-01
期刊:
NEUROCHEMISTRY INTERNATIONAL
影响因子:
4.2
作者:
[Ando, Masaki, Oku, Naoto, Takeda, Atsushi]
通讯作者:
Takeda, Atsushi
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