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Modulation and Impairment of learning and memory by hippocampal zinc

Modulation and Impairment of learning and memory by hippocampal zinc
海马锌对学习和记忆的调节和损害
批准号:
22390025
负责人:
TAKEDA Atsushi
金额:
$10.57万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012

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中文摘要
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英文摘要
Glutamatergic (zincergic) neurons are concentrated in the hippocampus, where Zn2+plays an important role in memory acquisition. The accepted mechanisms of memory are synaptic plasticity. Long-term potentiation (LTP) is known as a cellular model of synaptic plasticity. Zn2+multi-functionally modulates LTP induction in the hippocampus and is involved in memory acquisition . However,dyshomeostasis of synaptic Zn2+in the hippocampus, which is induced by stress, is involved in the impairment of memory. The present study demonstrated that synaptic Zn2+participates in acquisition and impairment of memory .
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Dynamic action of neurometals at the synapse.
神经金属在突触的动态作用。
DOI: --
发表时间: 2011
期刊: Metallomics
影响因子: 3.4
作者: [五味宏樹, 他, M.Tanaka, Haruna Tamano and Atsushi Takeda]
通讯作者: Haruna Tamano and Atsushi Takeda
Atsushi Takeda, Shunsuke Takada, Masatoshi Nakamura, Miki Suzuki, Haruna Tamano, Masaki Ando, and Naoto Oku
武田敦、高田俊介、中村正敏、铃木美纪、玉野春菜、安藤正树和奥直人
DOI: --
发表时间: 2011
期刊: PLoS One
影响因子: 3.7
作者: [Atsushi Takeda, Shunsuke Takada, Masatoshi Nakamura, Miki Suzuki, Haruna Tamano, Masaki Ando, and Naoto Oku]
通讯作者: and Naoto Oku
DOI: 10.1002/jnr.22787
发表时间: 2012
期刊: J.Neurosci.Res.
影响因子: --
作者: [Atsushi Takeda, et al]
通讯作者: et al
ニューロジンクの動態解析と脳機能制御
神经锌动态分析与脑功能控制
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [Katsu, K., Yokouchi, Y., 武田厚司]
通讯作者: 武田厚司
50
    Improvement of a liquid xenon detector for low threshold and high accuracy and search for anual modulation signals caused by dark matter particle using the detector
    • 批准号:
      25800132
    • 项目类别:
      Grant-in-Aid for Young Scientists (B)
    • 资助金额:
      $1.83万
    • 财政年份:
      2013
    • 负责人:
      TAKEDA Atsushi
    • 依托单位:
    Establishment of an efficient TALE-mediated genome editing in plants
    micro RNA as a novel biomarker for neurodegenerative diseses
    • 批准号:
      24659423
    • 项目类别:
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额:
      $2.33万
    • 财政年份:
      2012
    • 负责人:
      TAKEDA Atsushi
    • 依托单位:
    Waon: A Flexible Structured P2P Network
    • 批准号:
      23650032
    • 项目类别:
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额:
      $2.25万
    • 财政年份:
      2011
    • 负责人:
      TAKEDA Atsushi
    • 依托单位:
    海外基金