Physiological functions of polyunsaturated fatty acids and nutritional recommendation of the essential lipids for infants and toddlers

多不饱和脂肪酸的生理功能及婴幼儿必需脂类的营养推荐

• 批准号: 12670777
• 负责人: SHIMASAKI Hiroyuki
• 金额: $ 1.02万
• 依托单位: Teikyo University School of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2000
• 资助国家: 日本
• 起止时间: 2000 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12670777/
• 关键词: Essential fatty acid; polyunsaturated fatty acid; Brain lipid; Cholesterol; Infant formulas; 卵黄脂質; コレステロール代謝; ACAT; 脂質栄養; 成長と発達; 子白鼠; HMG-CoA還元酵素; 授乳期; 離乳期

Fatty acids have a variety of physiological functions such as energy supply, neural transmission, membrane structure, a precursor of biological active substances and etc. Long-chain polyunsaturated fatty acids (LCPUFA) which is essential for human development, is supplied to fetus and infants through cord blood and breast milk or/and infant formula, respectively, however, the mechanism still remains to be dissolved. We analyzed fatty acids from these materials and phospholipids from colostrum, comparing with that of infant formulas (IF) in Japan and recommended that PUFA should be added to the present infant formulas in Japan to produce better nutrition for infants and toddlers.

脂肪酸具有多种生理功能，如能量供应、神经传递、膜结构、生物活性物质的前体等。长链多不饱和脂肪酸（LCPUFA）是人体发育所必需的，分别通过脐带血和母乳或/和婴儿配方奶粉提供给胎儿和婴儿，但其机制仍有待研究。我们分析了这些材料中的脂肪酸和初乳中的磷脂，并与日本婴儿配方奶粉（IF）进行了比较，建议在日本现有的婴儿配方奶粉中添加PUFA，以提供更好的婴幼儿营养。

项目成果

S.Hanaka: "Developmental regulation of cholesterol metabolism in the brain"帝京医学雑誌. 24. 41-55 (2001)

S.Hanaka：“大脑中胆固醇代谢的发育调节”《帝京医学杂志》24. 41-55 (2001)。

金子衣野: "胎児、乳児の成長、発達に及ぼすn-3およびn-6系列多価不飽和脂肪酸の効果に関する栄養学的研究"帝京医学雑誌. 24(2). 107-118 (2001)

Kaneko Ino：“N-3 和 N-6 多不饱和脂肪酸对胎儿和婴儿生长发育影响的营养研究”Teikyo Medical Journal 24(2) (2001)。

Y. Shimizu, K. Arai, S. Ise, H. Shimasaki: "Dietary fish oil for hens affects the fatty acid composition of egg yolk phospholipids and gives a valuable food with an ideal balance of n-6 and n-3 essential fatty acids for human nutrition"J. Oleo Science,. 5

Y. Shimizu、K. Arai、S. Ise、H. Shimasaki：“母鸡饲料鱼油会影响蛋黄磷脂的脂肪酸组成，并提供一种具有 n-6 和 n-3 必需脂肪理想平衡的有价值的食物

H. Shimasaki, E. Yamashita, Y. Shimizu, S. Ise: "Dietary effect of docosahexaenoic acid-rich eggs on serum lipids in healthy human subjects: A randomized double-blind controlled study"J. Oleo Science,. 52. 109-119. (2003)

H. Shimasaki、E. Yamashita、Y. Shimizu、S. Ise：“富含二十二碳六烯酸的鸡蛋对健康人类受试者血脂的饮食影响：一项随机双盲对照研究”J.

S.Kaneko: "Long chain polyunsaturated fatty acids in cord blood and colostrum-"帝京医学雑誌. 24. 107-118 (2001)

S. Kaneko：“脐带血和初乳中的长链多不饱和脂肪酸 -”《Teikyo Medical Journal》24. 107-118 (2001)。