Repeated umbilical cord compression and periventiricular leubomalacia

反复脐带受压和脑室周围白质软化

• 批准号: 12671062
• 负责人: KOZUMA Shiro
• 金额: $ 2.18万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2000
• 资助国家: 日本
• 起止时间: 2000 至 2001
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12671062/
• 关键词: umbilical cord; periventricular leubomalacia; fetal sheep; 脳室周囲白室軟化症

We characterized the detailed hemodynamics of fetal blood pressure, heart rate, umbilical blood flow and carotid blood flow responses to partial compression of the umbilical cord and tested the hypothesis that repeated partial umbilical cord compression is a predisposing factor to genesis of periventricular leukomalacia. In chronically instrumented fetal sheep at 120-130 days of gestation, partial compression of the umbilical cord was induced 15 times, each for 2 min at 2 min intervals. Each cord copression reduced umbilical blood flow by 50%.In an early stage of the compression experiment, carotid arterial blood flow increased and carotic arterial resistance decreased, however, the resistance was gradually raised by repetition of compression and finally higher than the basal level. This result demonstrates that fetal brain circulation may be modified by preexposure to repeated intrauterine challenges.

我们详细描述了胎儿血压、心率、脐带血流量和颈动脉血流量对脐带部分受压的反应的血流动力学特征，并检验了反复的脐带部分受压是心室周围白质软化发生的一个易感因素的假设。在妊娠120-130天的胎羊中，诱导脐带部分受压15次，每次2分钟，间隔2分钟。每次脐带压迫可使脐带血流量减少50%。在压迫实验初期，颈动脉血流量增加，颈动脉阻力降低，但随着反复压迫，颈动脉阻力逐渐升高，最终高于基础水平。这一结果表明胎儿的脑循环可能会被反复暴露于宫内刺激而改变。

项目成果

Fujii T: "Theoretical basis for herbal medicines, Tokishakuyaku-san and Seirei-to, in the treatment of autoimmunity-related recurrent abortion"Am J Reprod Immunol. 44(6). 342-346 (2000)

Fujii T：“草药、Tokishakuyaku-san 和 Seirei-to 治疗自身免疫相关复发性流产的理论基础”Am J Reprod Immunol。

Fujii T: "Theoretical basis for herbal medicines, Tokishakuyaku-san and Gairei-to, in the treatment of autoimmunity-related recurrent abortion"Am J Reprod Immunol. 44(6). 342-346 (2000)

Fujii T：“草药、Tokishakuyaku-san 和 Gairei-to 治疗自身免疫相关复发性流产的理论基础”Am J Reprod Immunol。

Kanai T: "Human leukocyte antigen-G-expressing cells differently modulate the release of cytokines from mononuclear cells present in the decidua versus peripheral blood"Am J Reprod Immunol. 45(2). 94-99 (2001)

Kanai T：“表达人类白细胞抗原 G 的细胞以不同方式调节蜕膜中存在的单核细胞与外周血中存在的细胞因子的释放”Am J ReprodImmunol。

Uemura H.: "Amcable gestational Sac in association with a myometrial defect"Ultrasound Obstet Gynecol. 18(6). 675-677 (2001)

Uemura H.：“Amcable 妊娠囊与子宫肌层缺陷相关”超声妇产科。

Hiroi H: "Hyperemesis gravidarum associated with thyretoxicosis and a past history of an eating disorder"Arch Gynecol Obstet. 265(4). 228-230 (2001)

Hiroi H：“与甲状腺毒症相关的妊娠剧吐和饮食失调既往史”Arch Gynecol Obstet。