Fetal Stress as a Cause of Fetal Brain Damae

胎儿压力是胎儿脑损伤的原因

• 批准号: 14571046
• 负责人: KOZUMA Shiro
• 金额: $ 2.56万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2002
• 资助国家: 日本
• 起止时间: 2002 至 2003
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14571046/
• 关键词: brain damage; cardiac function; cord occlusion; fetal sheep; 胎児; 脳傷害; ヒツジ

It has been reported that umbilical cord occlusion is closely related to perinatal brain damage. We hypothesized that repeated umbilical cord occlusions cause fetal cardiac dysfunction, which is possibly related to brain hypoperfusion and injury. The purpose of this study is to investigate the effect of repeated umbilical cord occlusions on cardiac functions in fetal sheep.We inserted a conductance catheter into the left ventricle of the heart under ultrasound guidance to record pressur-volume curves of the left ventricle of the heart in 11 near-term fetal sheep. Umbilical cord was completely occluded five times for 60 seconds, five times for 90 seconds and five times for 120 seconds.Umbilical cord occlusions reduced stroke volume significantly throughout the experiments. During intervals of 90 seconds occlusion, fetal heart contractility and cardiac output increased Significantly compared with the control levels. However, stroke volume decreased significantly during intervals of 120 seconds occlusion. It is speculated that these changes in fetal cardiac function could be related to hypoxia, acidosis, and catecholamine secretion induce by repeated cord occlusions.

有文献报道脐带阻塞与围产期脑损伤密切相关。我们推测反复的脐带阻塞导致胎儿心脏功能障碍，这可能与脑灌注不足和损伤有关。为探讨反复脐带阻断对胎羊心功能的影响，在超声引导下将传导导管插入11只近足月胎羊左心室，记录左心室压力-容积曲线。脐带完全闭塞5次，每次60秒，5次，每次90秒，5次，每次120秒。在90秒阻断间隔内，胎儿心脏收缩力和心输出量与对照组相比显著增加。然而，每搏输出量在120秒闭塞间隔期间显著降低。推测这些胎儿心脏功能的变化可能与反复脐带阻断引起的缺氧、酸中毒和儿茶酚胺分泌有关。

项目成果

Saito M, Kozuma S, et al.: "Sonographic assessment of the cervix before, during and after a uterine contraction is effective in predicting the course of labor"Ultrasound Obstet Gynecol. 22. 604-608 (2003)

Saito M、Kozuma S 等人：“在子宫收缩之前、期间和之后对子宫颈进行超声评估可有效预测产程”Ultrasound Obstet Gynecol。

Zhang SQ, Fujii T: "Studies on fetal forelimb movements by using a wrist actigraph in sheep"Psychiatry Clin Neurosci.. 56(3). 283-284 (2002)

张顺庆，藤井泰：“利用羊腕活动记录仪研究胎儿前肢运动”《精神病学·临床神经科学》56（3）。

Kikuchi A, Marumo G, et al.: "Fractal tumor growth of ovarian cancer : sonographic evaluation."Gynecol Oncol.. 87(3). 295-302 (2002)

Kikuchi A、Marumo G 等人：“卵巢癌的分形肿瘤生长：超声评估。”Gynecol Oncol.. 87(3)。

Kikuchi A, Marumo G, et al.: "Fractal tumor growth of ovarian cancer: sonographic evaluation"Gynecol Oncol. 87(3). 295-302 (2002)

Kikuchi A、Marumo G 等：“卵巢癌的分形肿瘤生长：超声评估”Gynecol Oncol。

Zhang SQ Fujii T, et al.: "Studies on fetal forelimb movements by using a wrist actigraph in sheep."Psychiatry Clin Neurosci. 56(3). 283-284 (2003)

张 SQ Fujii T 等人：“使用绵羊腕部活动记录仪研究胎儿前肢运动。”精神病学临床神经科学。