Chronic umbilical cord compression and intrauterine growth retardation

慢性脐带受压和宫内生长迟缓

• 批准号: 10557098
• 负责人: KOZUMA Shiro
• 金额: $ 7.81万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 1998
• 资助国家: 日本
• 起止时间: 1998 至 2001
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-10557098/
• 关键词: umbilical cord; fetal sheep; hemodynamics; 子宮内胎児発育障害; 胎仔; 臍帯; 血流; 内分泌; 循環

In order to clarify the effect of chronic umbilical cord compression on fetal growth, we characterized the detailed hemodynamics of fetal blood pressure, heart rate, umbilical blood flow and carotid blood flow responses to partial umbilical cord compression. In chronically instrumented fetal sheep at 120-130 days of gestation, partial compression of the umbilical cord was induced 15 times, each for 2 min at 2 min intervals. Each cord copression reduced umbilical blood flow by 50%.The data obtained in this study has been under investigation.

为了阐明慢性脐带压迫对胎儿生长的影响，我们详细描述了胎儿血压、心率、脐血流和颈动脉血流对部分脐带压迫的反应。在妊娠120-130天的慢性仪器胎羊中，诱导脐带部分压迫15次，每次2 min，间隔2 min。每一次脐带压迫都会使脐带血流量减少50%。

项目成果

Uemura H: "A morable gestational sac in association with a myometrial defect"Ultrasound Obstet Gynecol. 18(6). 675-677 (2001)

Uemura H：“与子宫肌层缺陷相关的令人沮丧的妊娠囊”超声妇产科。

Fujii T: "Theoretical basis for herbal medicines, Tokishakuyaku-san and Soirei-to, in the treatment of autoimmunity-related recurrent abortion"Am J Reprod Immunol. 44(6). 342-346 (2000)

Fujii T：“草药、Tokishakuyaku-san 和 Soirei-to 治疗自身免疫相关复发性流产的理论基础”Am J Reprod Immunol。

G.Manuno,S.Kozuma, et al: "Generation of Periventricular feukomalacia by Repeated Umbilical Cord Occlusion in New-Term Fetal Sheep and its Possible Pathogenetical Mechanisms"Biology of the Neonate. 79(1). 39-45 (2001)

G.Manuno、S.Kozuma 等人：“新生胎羊反复脐带闭塞引起的脑室周围软化症及其可能的发病机制”新生儿生物学。

Kuroda K: "Prenatal evaluation of cephalopagus conjoined twins by means of three-dimensional ultrasound at 13 weeks of pregnancy"Ultrasound Obstet Gynecol. 16(3). 264-266 (2000)

Kuroda K：“妊娠 13 周时通过三维超声对头侧连体双胞胎进行产前评估”Ultrasound Obstet Gynecol。

Hiroi H.: "Hyperemesis gravidarum associated with thyrotoxicosis and a past history of an eating disorder"Arch Gynecol Obstet. 265(4). 228-230 (2001)

Hiroi H.：“与甲状腺毒症相关的妊娠剧吐和饮食失调既往史”Arch Gynecol Obstet。