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Experimental study of FR167653 on ischemia- reperfusion injury in canine simultaneous pancreas and kidney transplantation from non-heart-beating donor

FR167653对犬无心跳胰肾同步移植缺血再灌注损伤的实验研究

基本信息

批准号：
12671162
负责人：
SUGITANI Atushi
金额：
$ 2.18万
依托单位：
KYUSHU UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2000
资助国家：
日本
起止时间：
2000 至 2001
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12671162/
关键词：
ischemia-reperfusion cytokine FR167653 pancreas kidney 膵移植腎移植膵腎同時移植

项目摘要

1) We investigated the effect of FR167653 (FR) on ischemia-reperfusion (I/R) injury of the pancrearic tail in dogs. After subjecting to 90 min of warm ischemia, local and distant organs were injured. A control group and FR treatment group were evaluated for tissue blood flow, IVGTT, serum amylase and lipase levels, creatinine, liver enzymes, IL-1β m RNA in the peripheral blood, and PO_2 for three days. At postoperative day 3, the dogs were sacrificed and histopathology was evaluated for pancreas, kidney, lung, and liver. FR ameliorates I/R injury of the pancreas via reduction of inflammatory cytokines that may contribute to secondary damage to distant organs. We read this paper at the meeting of the Japan Society for Transplantation and this article appeared in SURGERY (SURGERY, 129 (3), 309-317).2) We succeeded in auto-transplantation of the pancreatic tail in dogs after subjecting to 60 minutes of warm ischemia. We investigated I/R injury in this model by the same way and confirmed the effectiveness of FR. We read this paper at the meeting of the Japan Society for Transplantation and this article is in submission to English journal.3) We investigated the effect of FR on renal I/R injury in dogs. We confirmed the effect of FR by the same way and read this paper at the meeting of the Japan Society for Transplantation. We submitted this article to SUEGERY and the revision is under judge.4) We succeeded in auto-transplantation of the kidney in dogs and are making investigation for the effect of FR. We also succeeded in auto-transplantation of simultaneous pancreas and kidney in dogs and making investigations.utes of ischemia, local and remote organs were injured via production of cytokines.

1) 我们研究了 FR167653 (FR) 对犬胰尾缺血再灌注 (I/R) 损伤的影响。经受90分钟的热缺血后，局部和远处器官受到损伤。对照组和FR治疗组检测组织血流、IVGTT、血清淀粉酶和脂肪酶水平、肌酐、肝酶、外周血IL-1β m RNA、PO_2，为期三天。术后第3天，处死狗并评估胰腺、肾脏、肺和肝脏的组织病理学。 FR 通过减少炎症细胞因子来改善胰腺的 I/R 损伤，炎症细胞因子可能导致远处器官的继发性损伤。我们在日本移植学会的会议上读到了这篇论文，这篇文章发表在《SURGERY》上（SURGERY, 129 (3), 309-317)。2) 在经历 60 分钟的热缺血后，我们成功地对狗进行了胰尾自体移植。我们以同样的方式研究了该模型中的 I/R 损伤，并证实了 FR 的有效性。我们在日本移植学会的会议上读到了这篇论文，这篇文章已提交给英文杂志。3) 我们研究了 FR 对狗肾 I/R 损伤的影响。我们以同样的方式确认了FR的效果，并在日本移植学会的会议上阅读了这篇论文。我们已将这篇文章提交给SUEGERY，正在审定中。4）我们成功地进行了狗的自体肾脏移植，正在研究FR的效果。我们还成功地在狗身上同时进行了胰腺和肾脏的自体移植，并进行了研究。缺血、局部和远端器官因细胞因子的产生而受到损伤。