Experimental and Clinical Studied for process of gastric carcinogenesis

对幽门螺杆菌(Hp)致癌过程进行了研究，获得了以下结果：1.幽门螺杆菌(Hp)致癌作用。结论1.在蒙古沙土鼠(MG)模型中，幽门螺杆菌和化学致癌物可诱发多种表型的胃癌，但肠化生可能只是部分肠型肿瘤的直接前驱物。在幽门螺杆菌与胃癌发生的关系中，幽门螺杆菌是促进剂而不是引发者，其他环境因素(致癌物投药时机)发挥着重要作用。Hp感染加十二指肠胃反流可促进MG模型大鼠胃粘膜细胞增殖。根除幽门螺杆菌减弱了幽门螺杆菌感染对胃腺癌发生的促进作用。根除幽门螺杆菌可能是预防胃癌的有效方法。在Hp感染早期，粘膜内PGE2水平升高和腺体粘液细胞高分泌粘蛋白对坏死剂诱导的胃粘膜损伤具有保护作用。结果表明，Hp感染后幽门黏膜中α4GnT基因的表达水平有升高趋势，提示Hp感染促进了腺体粘液细胞型粘蛋白的生物合成。

The process of gastric carcinogenesis concerning Helicobacter pylori ( Hp ) was studied, and following results were obtained.1. In Mongolian gerbil ( MG ) model Hp and chemical carcinogen induce several phenotype of gastric cancer, but intestinal metaplasia may be a direct precursor only in a subset of the intestinal-type tumors.2. In the relationship between Hp and gastric carcinogenesis, Hp is a promoter rather than an initiator, and other environmental factors ( the timing of carcinogen administration ) play important roles.3. Hp infection plus duodenogastric reflux increase cell proliferation in the gastric mucosa in MG model.4. Hp eradication diminishes enhancing effect of Hp infection on glandular stomach carcinogenesis in MGs. Hp eradication may be useful as a prevention approach against stomach cancer.5. In the early stage of Hp infection, accentuation of intramucosal PGE2 and hypersecretion of mucin from gland mucus cells have a protective effect against gastric mucosal injury induced by necrotizing agents.6. As results, the expression level of a 4GnT mRNA tended to be increased in the pyloric mucosa with Hp infection, suggesting that Hp infection enhances the biosynthesis of gland mucous cell-type mucin.