Identification of therapeutic target molecules againstatrial fibrillation: Use of the canine persistent atrial fibrillation model

抗房颤治疗靶分子的鉴定：犬持续性房颤模型的使用

• 批准号: 22590237
• 负责人: SUGIYAMA Atsushi
• 金额: $ 2.91万
• 依托单位: Toho University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22590237/
• 关键词: 心血管; 血液; 心房細動; 抗不整脈薬; Buchmann束; QT延長; torsades de pointes

The chronic persistent atrial fibrillation model was developedfirst. The complete atrioventricular block was produced to the beagle, the left atrium was equipped with the pacing electrode, and electric stimulus generating equipment was embedded at the right buttock subcutaneous part. Chronic persistent atrial fibrillation was induced by performing an electric stimulus (600 bpm) of an atrium for four weeks. Next, the existing drugs (pilsicainide, disopyramide, aprindine, cibenzoline), an I_Kurblocking agent (AVE0118), and oseltamivir were evaluated in this model. It became clear that oseltamivir has more potent antiarrhythmic effect than the existing anti-atrial fibrillation drugs.

首先建立了慢性持续性房颤模型。将Beagle犬造成完全性房室传导阻滞，左心房植入起搏电极，右心房皮下植入电刺激发生装置。通过对心房进行电刺激（600 bpm）4周来诱导慢性持续性房颤。接下来，在该模型中评价了现有药物（匹西卡尼、丙吡胺、阿普林定、西苯唑啉）、I_Kur阻断剂（AVE 0118）和奥司他韦。很明显，奥司他韦比现有的抗房颤药物具有更强的抗心律失常作用。

项目成果

オセルタミビルの心血行動態および電気生理学的作用

奥司他韦对心脏血流动力学和电生理学的影响

• 发表时间: 2013
• 作者: 北原 健;中村裕二;恒岡弥生;赤羽悟美;田中 光;山崎浩史;高原章;山崎純一;池田隆徳;杉山 篤
• 通讯作者: 杉山 篤

Cardiohemodynamic and Electrophysiological Effects of Anti-influenza Drug Oseltamivir In Vivo and In Vitro

• DOI: 10.1007/s12012-013-9202-6
• 发表时间: 2013-09-01
• 期刊: CARDIOVASCULAR TOXICOLOGY
• 影响因子: 3.2
• 作者: Kitahara, Ken;Nakamura, Yuji;Sugiyama, Atsushi
• 通讯作者: Sugiyama, Atsushi

Measurements of Cardiac Ion Channel Subunits in the Chronic Atrioventricular Block Dog

• DOI: 10.1254/jphs.11019sc
• 发表时间: 2011-05-01
• 期刊: JOURNAL OF PHARMACOLOGICAL SCIENCES
• 影响因子: 3.5
• 作者: Takahara, Akira;Wagatsuma, Hirotaka;Sugiyama, Atsushi
• 通讯作者: Sugiyama, Atsushi