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The Research for Intercostal Artery as in situ Graft on CABG against Ischemic Heart Disease

肋间动脉原位移植冠状动脉搭桥术治疗缺血性心脏病的研究

基本信息

批准号：
12671313
负责人：
IWANAGA Hiroshi
金额：
$ 2.24万
依托单位：
Ehime University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2000
资助国家：
日本
起止时间：
2000 至 2003
项目状态：
已结题

项目摘要

However the arterial grafts such as internal thoracic arteries (ITAs), radial arteries and gastroepiploic arteries may nave long-term patency in the coronary artery bypass grafting (CABG), few have concerned about the intercostal arteries (ICAs) which may have the potency of candidate for substitute grafts. SO we focused on the ICAs and got as follows. The human ICAs, in fact, constitute small diameters compared to ITAs and are subject to have low flow, volumes. And porcine ICAs showed lower vascular functions compared to coronary arteries or GEAs when they were performed by organ bath examinations. These results may indicate the need for better conditions in the preservation against small diameter arteries. In the nest step we evaluated the functional activities of thoracic arteries from rats in the mediums of different constitution, in the different pH conditions, in the addition of Angiotensin II type 1 receptor blocker (ARB) and in the cryopreserved conditions, resulting that Krebs-Henseleit buffer gave the arteries functional stabilization until 6hrs in the preservation at 37 centigrades that pH of the medium had a great effect on the functional activities of the arteries, that ARB improved the functional activities of the arteries exposed to angiotensin II and that the functional activities changed in time-dependent manner at -80 centigrades. We concluded that it is needed to continue to research arterial grafts for CABG and it is important to preserve the functional activities in the treatment of small diameter arteries such as intercostal arteries.

然而，胸廓内动脉（ITA）、桡动脉和胃网膜动脉等动脉移植物在冠状动脉旁路移植术（CABG）中可能具有长期通畅性，很少有人担心肋间动脉（ICAs）可能具有替代移植物的潜力。所以我们专注于 ICA 并得到如下结果。事实上，与 ITA 相比，人类 ICA 的直径较小，并且流量较小。当进行器官浴检查时，与冠状动脉或 GEA 相比，猪 ICA 的血管功能较低。这些结果可能表明需要更好的条件来保存小直径动脉。在接下来的步骤中，我们评估了大鼠胸动脉在不同成分的培养基、不同pH条件、添加血管紧张素II 1型受体阻滞剂(ARB)和冷冻保存条件下的功能活动，结果Krebs-Henseleit缓冲液使动脉功能稳定，直到37摄氏度保存6小时，培养基的pH对胸动脉的功能活动有很大影响。动脉，ARB 改善了暴露于血管紧张素 II 的动脉的功能活动，并且功能活动在 -80 摄氏度时以时间依赖性方式发生变化。我们的结论是，需要继续研究冠状动脉搭桥术的动脉移植物，并且在治疗肋间动脉等小直径动脉时保持功能活性非常重要。