EVALUATION OF BLOOD FLOW IN THE BONE BY DYNAMIC MRI

通过动态 MRI 评估骨骼中的血流

• 批准号: 12671390
• 负责人: GOTOH Eiji
• 金额: $ 0.58万
• 依托单位: ASAHIKAWA MEDICAL COLLEGE
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2000
• 资助国家: 日本
• 起止时间: 2000 至 2001
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12671390/
• 关键词: MRI; BONE MARROW; FEMORAL HEAD; BLOOD FLOW; NECROSIS; FEMORAL NECK FRACTURE; 犬

We evaluated the blood flow in the bone by using dynamic MRI in experimental study.Experiment 1: We made a femoral neck fracture surgically in dogs and analyzed the changes of signal intensity in the femoral head by dynamic MRI. Although the significant decrease of signal intensity was observed immediately after injection of Gd in the control side, no change of signal intensity was detected in the experimental side. In the prostata which has rich blood flow, same pattern of changes of signal intensity was observed. This phenomenon was thought to be so called suceptibility effects which mean the presence of blood flow in MRI findings of brain. From these results, acute decrease of signal intensity after Gd injection thought to be the proof of blood flow in the bone.Experiment 2: We made dynamic MRI in normal adults without disease of hip joint. The signal intensity decreased in 20 〜 30 seconds after injection of Gd. This pattern of changes of intensity was same as that of animal experiment. We indicated the possibility of measurement of blood flow in the bone by using MRI in clical study.

实验一：用动态MRI观察犬股骨颈骨折后股骨头内血流信号的变化。在对照侧注射Gd后，信号强度立即显著降低，但在实验侧未检测到信号强度的变化。在血流丰富的前列腺中，观察到相同的信号强度变化模式。这种现象被认为是所谓的可感知性效应，这意味着在脑的MRI结果中存在血流。实验二：对无髋关节病变的正常成人进行动态MRI检查。注射Gd后20 ~ 30秒信号强度下降。这种强度变化规律与动物实验结果一致。本文提出了用MRI测量骨内血流量的可能性。

项目成果

寺西 正, 後藤英司, 稲尾茂則, 松野丈夫, 安藤御史, 岡本哲軌: "Charnley型人工股関節置換術-15年以上経過例の成績-"骨・関節・靭帯. 13(1). 35-39 (2000)

Tadashi Teranishi、Eiji Goto、Shigenori Inao、Takeshi Matsuno、Masashi Ando、Tetsuki Okamoto：“Charnley 型髋关节置换术 - 15 年以上病例的结果 -” 骨、关节和韧带 13(1)。 2000)

高桑昌幸, 後藤英司, 稲尾茂則, 研谷 智, 寺西 正, 松野丈夫: "Triple osteotomyの術後長期成績"Hip Joint. 26. 309-312 (2000)

Masayuki Takakuwa、Eiji Goto、Shigenori Inao、Satoshi Kenya、Tadashi Teranishi、Takeshi Matsuno：“三重截骨术的长期术后结果” 26. 309-312 (2000)。

後藤英司, 寺西 正: "Charnly式人工股関節置換術の術後20年におけるX線成績"整形外科. 53巻3号. 249-254 (2001)

Eiji Goto，Tadashi Teranishi：“Charnly 髋关节置换术 20 年后的 X 射线结果”，《骨科》第 53 卷，第 3 期，249-254（2001 年）。

T. MAAEDA, E. GOTOH, T. TERANISHI, T. MATSUNO: "Can we evluate the blood flow in the bone by using dynamic MRI?"SEIKEIGEKA. 38. 19-23 (2000)

T. MAAEDA、E. GOTOH、T. TERANISHI、T. MATSUNO：“我们可以使用动态 MRI 来评估骨骼中的血流吗？”SEIKEIGEKA。

後藤 英司, 寺西 正: "Chanly式人工股関節置換術の術後20年におけるX線成績"整形外科. 53巻3号. 249-254 (2001)

Eiji Goto，Tadashi Teranishi：“Chanly 髋关节置换术后 20 年的 X 射线结果”《骨科》第 53 卷，第 3 期 249-254（2001 年）。