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Role of brain natriuretic peptide in arterial pressure regulation

脑钠肽在动脉压调节中的作用

基本信息

批准号：
01570501
负责人：
GOTOH Eiji
金额：
$ 1.15万
依托单位：
Yokohama City University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1989
资助国家：
日本
起止时间：
1989 至 1991
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-01570501/
关键词：
barin natriuretic peptide c-type natriuretic peptide central nervous system arterial blood pressure sympathetic nervous system angiotensin II 高張食塩水脳室内投与動脈圧ラット

项目摘要

The brain and sympathetic nervous (SN) system play important roles in cardiovascular regulation. Central administration of atrial natriuretic peptide (ANP) has been reported to oppose pressor response to centrally administered angiotensin (A) II. Recently, two new types of natriuretic peptides were found in the porcine brain, termed brain natriuretic peptide (BNP) and C-type natriuretic peptide (CNP). To examine the central action of BNP or CNP on blood pressure, we infused rat-BNP or CNP into the third ventricle and measured arterial blood pressure (AP) and plasma vasopressin (VP) concentration in inactin-anesthetized rats. 1. Although high doses of BNP or CNP produced reductions in AP, these doses, when given intravenously, similarly decreased AP. Plasma VP was decreased. 2. Hypertonic saline or AII given to the ventricle produced significant increases in AP and plasma VP. But BNP or CNP inhibited AP and VP responses to hypertonic saline or AII. These central actions of BNP or CNP we … More re equivalent to those of ANP. 3. Salt-sensitive hypertensive Dahl S rats were subjected. Central administration of high doses of BNP caused significant decreases in AP, but these doses, when given intravenously, showed similar depressor effects. Furthermore, centrally administered BNP did not affect the baroreceptor-mediated reflex function. These data suggest that, in the brain, BNP or CNP as well as ANP antagonizes AII or NaCl in terms of the effects on blood pressure and VP secretion.Circulating AII has been reported to stimulate SN activity, and ANP may antagonize the SN response to AII. To investigate the interactions between circulating AII and ANP for blood pressure and SN activity, we did intravenous infusions of AII and ANP and measured AP and muscle SN activity in human. Intravenous infusions of AII enhanced SN activities but simultaneous infusions of ANP attenuated the responses. Although the mechanism by which circulating ANP opposes the actions of circulating AII has not been elucidated, it could be related to the interaction between the two peptides in the brain as shown in our studies. Less

大脑和交感神经系统在心血管调节中起着重要作用。心房利钠肽（ANP）的中央管理有报道反对压力反应中央管理血管紧张素(A) II。近年来，在猪脑中发现了两种新的利钠肽，分别为脑利钠肽（BNP）和c型利钠肽（CNP）。为了研究BNP或CNP对血压的中枢作用，我们将大鼠BNP或CNP注入第三心室，测量了失活素麻醉大鼠的动脉血压（AP）和血浆加压素（VP）浓度。1. 虽然高剂量BNP或CNP可降低AP，但静脉给药时，这些剂量同样可降低AP。血浆VP降低。2. 心室高渗盐水或AII使AP和血浆VP显著升高。但BNP或CNP抑制AP和VP对高渗盐水或AII的反应。BNP或CNP的这些核心作用与ANP相当。3. 盐敏感型高血压大鼠。中央给药高剂量BNP导致AP显著降低，但静脉给药时，这些剂量显示出类似的抑制作用。此外，中央给药BNP不影响压力感受器介导的反射功能。这些数据表明，在大脑中，BNP或CNP以及ANP在对血压和VP分泌的影响方面拮抗AII或NaCl。据报道，循环AII可刺激SN活性，ANP可拮抗SN对AII的反应。为了研究循环AII和ANP对血压和SN活性的相互作用，我们进行了AII和ANP静脉输注，并测量了人体AP和肌肉SN活性。静脉输注AII可增强SN活性，同时输注ANP可减弱SN活性。虽然循环ANP对抗循环AII作用的机制尚未阐明，但我们的研究表明，这可能与大脑中两种肽之间的相互作用有关。少