Central genotyping services, coordination and quality control

中央基因分型服务、协调和质量控制

• 批准号: 5310736
• 负责人: Professor Dr. Stefan Schreiber
• 金额: --
• 依托单位: Abteilung Molekulare Humangenetik (aufgelöst)
• 依托单位国家: 德国
• 项目类别: Research Units
• 财政年份: 2001
• 资助国家: 德国
• 起止时间: 2000-12-31 至 2006-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/5310736?language=en
• 关键词: Central; genotyping; services; coordination; quality

The projects of the research group are pursuing a systematic approach towards the identification of disease genes. This approach targets the genetic component of the etiology, and is known as positional cloning. A successful positional cloning heavily depends on high standards in high-throughput genotyping, since massive amounts of precise genotypes are instrumental. Minor error rates are amenable for potential failure of ambitious projects. Within the research group, project Q2 coordinates all high-throughput genotyping efforts and implements all measures of quality control and accounting. Problems of data quality and of resource allocation are addressed and balanced accordingly. The pertinent organizational structures are allocated to Q2. Relevant software and computational tools are developed and deployed by Q2, too. The close cooperation with the genotyping centers in Berlin, Kiel, and Munich is to be continued.

该研究小组的项目正在寻求一种系统的方法来识别疾病基因。这种方法针对病因学的遗传成分，被称为定位克隆。成功的定位克隆在很大程度上取决于高通量基因分型的高标准，因为大量的精确基因型是有用的。微小的错误率可能会导致雄心勃勃的项目失败。在研究小组内，Q2项目协调所有高通量基因分型工作，并实施所有质量控制和核算措施。数据质量和资源分配问题得到相应处理和平衡。相关的组织结构分配给Q2。Q2也开发和部署了相关的软件和计算工具。与柏林、基尔和慕尼黑基因分型中心的密切合作将继续进行。