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The development of new three-dimensional ultrasound system and its examination of utility for the purpose of ultrasonic characterization of human fetal brain tissue

新型三维超声系统的开发及其对人类胎儿脑组织超声表征的实用性检验

基本信息

批准号：
12557139
负责人：
NAKANO Hitoo
金额：
$ 6.91万
依托单位：
Kyushu University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2000
资助国家：
日本
起止时间：
2000 至 2002
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-12557139/
关键词：
Fetus Three dimensional Ultrasound Fetal behavior

项目摘要

The Volume-mode is a useful method to model three-dimensional ultrasound image, which is a relatively new modality with several potent advantages over conventional two-dimensional one, because it is based on accurate positional information. However, as this method requires long time to examine, it has been difficult to get real-time image. In this investigation, we developed the high-speed scanning probe and observed the fetal real-time movement.The General Movement (GM), whose elegance and continuity is known to reflect central nervous system function in neonates, can be observed since 8-9 weeks of gestation in human fetuses. Hepper et al. reported that abnormal GM relates miscarriage in the first trimester. Visser et al. reported that fetal GM is similar to those of neonates. However, these observations were done using B-mode scan, thus it has been impossible to evaluate quantitatively.We adopted this high-speed scanning probe to observe fetal GM and investigate on the relationship among the movements in each limbs. As a result, we found significant similarity between fetal GM and that of neonates in the relationship among the movements in each limbs. Although it was also expected to enable tissue characterization using this probe, it is still hard to detect fine structures in fetal hippocampus. It seemed to be required further technical improvement especially in hardware.In summary, 1) we developed a new device which can observe fetal real-time movement, and found that 2) fetal GM in the first trimester is similar to that of neonates. 3) Fine tissue characterization in fetal brain is remained as a further assignment to be addressed.

体积模式是一种有用的方法来建模三维超声图像，这是一个相对较新的模式与传统的二维一个有几个潜在的优势，因为它是基于准确的位置信息。但是，由于这种方法需要长时间的检查，它一直难以得到实时图像。本研究利用高速扫描探头对胎儿运动进行实时观察，发现胎儿全身运动（generalmovement，GM）从孕8-9周开始就可以观察到，GM的优美性和连续性反映了新生儿中枢神经系统的功能。Hepper等人报道GM异常与妊娠早期流产有关。Visser等人报告称，胎儿GM与新生儿相似。但这些观察都是用B超进行的，无法定量评价，我们采用这种高速扫描探头观察胎儿GM，并探讨各肢体运动之间的关系。结果发现，胎儿GM与新生儿GM在各肢体运动之间的关系上具有显著的相似性。虽然它也被期望能够使用该探针进行组织表征，但仍然难以检测胎儿海马中的精细结构。综上所述，1）我们开发了一种新的实时监测胎儿运动的装置，发现2）胎儿在孕早期的GM与新生儿的GM相似。3)胎儿脑组织的精细定征仍有待进一步研究。