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The overall study of the pulp and periodontal ligament of replanted tooth - The change of sensory nerve and the development of root end filling material -

再植牙牙髓及牙周膜的整体研究-感觉神经的变化与根端充填材料的发展-

基本信息

批准号：
12671858
负责人：
KUBOTA Minoru
金额：
$ 2.18万
依托单位：
Iwate Medical University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2000
资助国家：
日本
起止时间：
2000 至 2002
项目状态：
已结题

项目摘要

The nociceptive neurons responding to noxious stimuli of the tooth, oral mucous or facial skin were recorded in the ventral posteromedial nucleus (VPM), and the posterior thalamic group (PO) and the zona incerta (ZI) in the diencephalon. These neurons were classified into the low threshold mechanoreceptive neurons, wide dynamic range neurons and nociceptive-specific neurons. Functional segregation of these nociceptive neurons was not apparent within the nucleus or between nuclei.The nociceptive neurons are also recorded at the trigeminal caudal nucleus and the reticular subnuclei in the medulla oblongata. These nurons were divided into three groups depending their response pattern, (1) neurons with a latency of less than 30 msec, (2) those with a latency of more than 30 msec and (3) those with both latency. The nociceptive neurones showed all these response pattern, but the low threshold mechanoreceptive (LTM) neurons responded with the pattern of (1) suggesting the input from A-fiber.The composition and properties of experimental and commercial bone grafting gypsum was evaluated. The experimental bone grafting gypsum was revealed that was calcium phosphate hemihydrate. The arsenic concentration of experimental bone grafting gypsum was under the detection limit (0.2 ppm) and lower level than the other materials.The biocompatibility of the experimental bone grafting gypsum was tested at the periapical portion of the replanted rat incisor. In the control group, the reinforced eugenol cement was filled as root end filling material. The cement was not absorbed until four weeks after operation and the inflammation was still observed until four weeks after operation. In the experimental group, the experimental bone grafting gypsum was filled as root end filling material. The experimental bone grafting gypsum was absorbed until two weeks after operation and the inflammation went out until four weeks after operation.

对牙齿、口腔粘液或面部皮肤的伤害性刺激做出反应的伤害性神经元记录在腹侧后内侧核（VPM）、后丘脑组（PO）和间脑的未定带（ZI）中。这些神经元被分为低阈值机械感受神经元、宽动态范围神经元和伤害感受特异性神经元。这些伤害性神经元的功能分离在细胞核内或细胞核之间并不明显。在三叉神经尾核和延髓的网状亚核处也记录到了伤害性神经元。这些神经元根据其反应模式分为三组：(1) 潜伏期小于 30 毫秒的神经元，(2) 潜伏期超过 30 毫秒的神经元，(3) 两者都有潜伏期的神经元。伤害感受神经元表现出所有这些反应模式，但低阈值机械感受（LTM）神经元的反应模式为（1），表明来自A-纤维的输入。对实验和商业骨移植石膏的成分和性能进行了评估。结果表明，实验用的植骨石膏是半水磷酸钙。实验植骨石膏的砷浓度低于检测限（0.2 ppm），低于其他材料的水平。在大鼠再植切牙根尖部测试实验植骨石膏的生物相容性。对照组则采用增强丁香酚水门汀作为根端充填材料。骨水泥直到术后4周才被吸收，直到术后4周仍观察到炎症。实验组采用实验植骨石膏作为根端充填材料。实验性植骨石膏到术后两周才被吸收，炎症到术后四周才消退。

项目成果

期刊论文数量（7）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

村田純一郎, 松本範雄: "ラットの三叉神経脊髄路核尾側核および網様亜核の侵害受容細胞に対する扁桃体条件刺激の抑制効果"岩手医科大学歯学雑誌. 27. 246-260 (2002)

Junichiro Murata、Norio Matsumoto：“杏仁核条件性刺激对大鼠三叉神经脊髓束核尾核和网状亚核中伤害感受细胞的抑制作用”岩手医科大学牙科杂志 27. 246-260 (2002)。

DOI：
发表时间：
期刊：
影响因子：
0
作者：
通讯作者：

工藤義之, 南清隆, 橋本正則, 菊地正浩, 柳谷隆仁, 植田正彦, 久保田稔: "石膏系骨補填材料の試作および理工学的性質"日本歯科保存学雑誌. 45・6. 515-521 (2002)

Yoshiyuki Kudo、Kiyotaka Minami、Masanori Hashimoto、Masahiro Kikuchi、Takahito Yanagiya、Masahiko Ueda、Minoru Kubota：“石膏基骨替代材料的原型和工程特性”日本保守牙科杂志 45・6（2002 年）。）

DOI：
发表时间：
期刊：
影响因子：
0
作者：
通讯作者：

工藤義之, 南清隆, 橋本正則, 菊地正浩, 柳谷隆仁, 植田正彦, 久保田稔: "石膏系骨補填材料の試作および理工学的性質"日本歯科保存学雑誌. 45. 515-521 (2002)

Yoshiyuki Kudo、Kiyotaka Minami、Masanori Hashimoto、Masahiro Kikuchi、Takahito Yanagiya、Masahiko Ueda、Minoru Kubota：“石膏基骨替代材料的原型和工程特性”日本保守牙科杂志 45. 515-521 (2002)。