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Study on the Influence of Environmental Hormone to Cleft Lip and/or Palate

环境激素对唇腭裂影响的研究

基本信息

批准号：
12671976
负责人：
NIIMI Teruyuki
金额：
$ 1.92万
依托单位：
Aichi-Gakuin University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2000
资助国家：
日本
起止时间：
2000 至 2002
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12671976/
关键词：
environmental hormone cleft lip and or palate mouse BisPhenolA teratogenicity

项目摘要

Purpose : Maternal environmental factors have much influence on the occurrence of cleft lip and/or palate. As incidence of cleft lip and/or palate in CLP-prone A/J strain mouse decreases by administrating estradiol, it is suggested that various hormones affect facial generation. As environmental hormone acts like female hormone, its influence to human body is concerned. Therefore, we studied about the influence of environmental hormone to cleft lip and/or palate.Method : We used A/J strain mouse (Japan SLC) for experiment. As incidence of cleft lip and/or palate decreases to a minimum when estrogen is administered on the 9^<th> gestation day, BisPhenolA was administered on the 9_<th> gestation day. Amount of BisPhenolA administered was 0, 0.1, 10mg/kg each. Incidence of cleft lip and/or palate was investigated on the 18^<th> gestation day.Result : Incidence of cleft lip and/or palate in the control group was 7.82%. Incidence of cleft lip and/or palate in 1.01mg/kg group was 4.08%, 1.96 … More % in 0.1mg/kg group, 4.91% in 1mg/kg group and 7.31% in 10mg/kg group. Though incidence of cleft lip and/or palate decreased in the group administered 0.01mg/kg BisPhenolA and 0.1mg/kg group, incidence increased as amount increased.Discussion : Molecular of BisPhenolA is so small that it reaches fetus through placenta. It combines with estrogen receptor and acts like female hormone. As cephalo neural crest cell has an important role in maxillofacial generation, it is well known that interruption of its move or growth causes congenital anomalies like cleft lip and/or palate. It was considered that move of neural crest cell is almost completed in the BisPhenolA administered fetus at 9^<th> day, BisPhenolA acted to the cell and promoted its proliferation. Also, environmental hormone in large amounts induces congenital anomalies like cleft lip and/or palate. Therefore, it suppressed incidence of cleft lip and/or palate for 0.1mg/kg administered group, but it showed teratogenicity for 1mg/kg and 10mg/kg groups and incidence of cleft lip and/or palate increased. Less

目的：母亲的环境因素对唇腭裂的发生有很大的影响。雌二醇可降低CLP易感A/J系小鼠唇腭裂发生率，提示多种激素影响颜面发育。由于环境激素与雌性激素的作用相似，其对人体的影响备受关注.为此，本研究探讨了环境激素对唇腭裂发生的影响。当在妊娠第9天给予雌激素时，由于唇裂和/或腭裂的发生率降至最低<th>，因此在妊娠第9天给予BisPhenolA<th>。BisPhenolA的给药量分别为0、0.1、10 mg/kg。结果<th>：对照组唇腭裂发生率为7.82%，对照组唇腭裂发生率为7.82%。1.01mg/kg组唇腭裂发生率分别为4.08%、1.96 ...更多信息 1 mg/kg组为4.91%，10 mg/kg组为7.31%。虽然0.01mg/kg BisPhenolA组和0.1mg/kg BisPhenolA组的唇腭裂发生率降低，但发生率随着剂量的增加而增加。它与雌激素受体结合，作用类似于雌性激素。由于头神经嵴细胞在颌面部发育过程中起着重要作用，因此，众所周知，其运动或生长的中断会导致唇腭裂等先天性畸形。认为BisPhenolA给药后第9天胎仔神经嵴细胞运动基本完成<th>，BisPhenolA对神经嵴细胞起作用，促进其增殖。此外，大量的环境激素会导致先天性畸形，如唇腭裂。因此，0.1 mg/kg给药组可抑制唇裂和/或腭裂的发生率，但1 mg/kg和10 mg/kg给药组显示致畸性，唇裂和/或腭裂的发生率增加。少