Study on effects of endocrine disrupter on cleft lip and/or palate.

内分泌干​​扰物对唇裂和/或腭裂影响的研究。

• 批准号: 20592352
• 负责人: NIIMI Teruyuki
• 金额: $ 2.66万
• 依托单位: Aichi Gakuin University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20592352/
• 关键词: ビスフェノールA; 口唇裂; 先天異常; 予防; 胸腺

As an environmental factor, the inhibition of the production of urokinase-type plasminogen activator (u-PA) as a marker of vascular development was studied using bisphenol A (BPA). The u-PA production was not inhibited by BPA. On the other hand, the metabolism of folate affects the cause of cleft lip and/or palate. To clarify this point, several gene expressions related with folate metabolism were determined.It is suggested that BPA is likely to partly modulate the transcription of the genes involved in bone metabolism through retinoic acid receptor, resulting in the suppression of the development of a cleft lip and/or palate. Further, through the comprehensive screening of natural retinoic acid receptor or estrogen receptor agonists to prevent the development of a cleft lip and/or palate, we isolated a few RAR agonists from crude drugs used in Kampo medicines.

作为一种环境因素，研究了双酚A（BPA）对作为血管发育标志物的尿激酶型纤溶酶原激活物（u-PA）产生的抑制作用。BPA不抑制u-PA的产生。另一方面，叶酸的代谢影响唇裂和/或腭裂的原因。为了阐明这一点，我们测定了几个与叶酸代谢相关的基因表达，结果表明BPA可能通过维甲酸受体部分调节骨代谢相关基因的转录，从而抑制唇腭裂的发生。此外，通过全面筛选天然维甲酸受体或雌激素受体激动剂，以防止唇腭裂的发展，我们从汉方药物中使用的原料药中分离出一些RAR激动剂。

项目成果

レチノイン酸受容体アゴニスト剤

视黄酸受体激动剂

• 发表时间: 2010