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Study of Environmental Factor on Occurrence of Cleft Lip and/or Palate by Fertilized Ovum Transplantation

受精卵移植引起唇裂和/或腭裂的环境因素研究

基本信息

批准号：
15592146
负责人：
NIIMI Teruyuki
金额：
$ 2.05万
依托单位：
Aichi-Gakuin University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2003
资助国家：
日本
起止时间：
2003 至 2004
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15592146/
关键词：
Fertilized Ovum Transplantation Cleft Lip Cleft Palate Cardiovascular Anomaly Anomaly Thymic Anomaly Congenital Anomaly Mouse

项目摘要

I. We carried out transplantation and implantation of fertilized ovum between the same strain mice and between the different strain mice and studied about the prevalence of congenital anomalies such as cleft lip and/or palate, cardiovascular and thymic anomalies. We obtained the following results.1. Fertilized ova of pro-CLP strain transplanted to anti-CLP strain was suppressed the occurrence of CLP, cardiovascular and thymic anomalies.2. Fertilized ova of anti-CLP strain transplanted to pro-CLP strain did not cause congenital anomalies.3. It is suggested that about the multiple anomaly within high incidence family, multi-generic diseases can be suppressed by environmental changes.II. We administered folic acid to A/J strain mice with the amount equivalent to 0.8mg/day per a person between the period of 2 weeks before pregnancy and 13 gestation day, and 0.4mg/day per a person between the period of 14 gestation day and 18 gestation day. We studied about the influence of folk acid to the … More fetus body weight and incidence of CLP among fetuses and obtained the following results.1. Resorption rate was 12.3% in the control group and 10.2% in the experimental group (0.8mg administered) respectively, showing no significant difference between them.2. About the average weight of fetuses, while both experimental groups (10mg administered and 1mg administered) decreased significantly compared to the control group, experimental group (0.8mg administered) did not decrease, not showing significant difference compared to the control group.3. While the incidence of CP only of 10mg group and 1mg group decreased showing significant difference compared to the control group, 0.8mg group showed no suppression effect.4. Incidence of CL/P in all of 10mg, 1mg and 0.8mg experimental groups did not decrease showing no significant differences compared to the control group.These results suggest that 0.8mg administration of folic acid on the period from pre-pregnancy to organogenesis, 0.4mg administration of folic acid on fetus growing stage can prevent weight decrease. Further study is thought to make it possible to prevent CL/P. Less

I.我们进行了同品系小鼠之间和不同品系小鼠之间的受精卵移植和植入，并研究了先天性畸形如唇腭裂、心血管和胸腺畸形的患病率。我们得到了以下结果。1.亲CLP品系受精卵移植到抗CLP品系后，CLP、心血管和胸腺异常的发生受到抑制.将抗CLP株受精卵移植到亲CLP株上，未引起先天性畸形.提示对于高发家系内的多重异常，环境变化可以抑制多属性疾病的发生。本实验对A/J系小鼠在妊娠前2周至妊娠13天期间给予相当于0.8mg/人/日的叶酸，在妊娠14天至妊娠18天期间给予相当于0.4mg/人/日的叶酸。我们研究了民间酸对 ...更多信息结果：1.胎儿体重及CLP发生率.对照组吸收率为12.3%，实验组吸收率为10.2%（0.8mg），两组比较差异无统计学意义.关于胎仔平均体重，虽然两个实验组（10 mg给药组和1 mg给药组）均较对照组显著降低，但实验组（0.8mg给药组）未降低，与对照组相比无显著差异.而10 mg组和1 mg组仅CP发生率降低，与对照组相比有显著性差异，0.8mg组无抑制作用. 10 mg、1 mg和0.8mg剂量组CL/P发生率均未降低，与对照组比较无显著性差异，提示孕前至器官形成期给予0.8mg叶酸和胎儿生长期给予0.4mg叶酸可预防体重下降。进一步的研究被认为有可能预防CL/P。