Pharmaceutical activity of ubiquinone analogs

泛醌类似物的药物活性

• 批准号: 12672164
• 负责人: MORI Koichi
• 金额: $ 2.11万
• 依托单位: Kobe Gakuin University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2000
• 资助国家: 日本
• 起止时间: 2000 至 2001
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12672164/
• 关键词: ubiquinone; ubiquinone analog; antioxidant; lipid peroxidation; free radical; mitochondira; ubiquinone; ubiquinone amalog; antioxidant; lipid peroxidation; free radical; 抗酸化作用; 活性酸素; アストロサイト

New alkyl-l, 4-naphthoquinone, and alkylthio- or arylthio-2, 6-dimethyl-l, 4-benzoquinone as ubiquinone analog were synthesized and tested for the effect on the respiratory chain system and lipid peroxidation in bovine heart mitochondria (BHM). These quinones showed weak inhibitory activities on the respiratory system in BHM. The several compounds of these quinones were efficient as exogenous ubiquinone-10 for the inhibition of lipid peroxidation. The chemical reactivity toward peroxy radicals was investigated in n-hexane, and assessed by in the competition with N, N'-diphenyl-p-phenylenediamine and their antioxidant potency was evaluated in the oxidation of methyl linoleate in hexane. The potency was assessed by the extent of the reduction in the rate of oxidation and duration of inhibition period.

合成了新的烷基-1，4-萘醌和烷硫基或芳硫基-2，6-二甲基-1，4-苯醌类泛醌，并研究了它们对牛心肌线粒体（BHM）呼吸链系统和脂质过氧化的影响。这些醌类化合物对BHM的呼吸系统有较弱的抑制作用。这些醌类化合物的几个有效的外源泛醌-10抑制脂质过氧化。在正己烷中研究了对过氧自由基的化学反应性，并通过与N，N '-二苯基-对苯二胺的竞争来评估，并在亚油酸甲酯在己烷中的氧化中评估了它们的抗氧化效力。通过氧化速率降低的程度和抑制期持续时间评估效价。