Metabolism of polychlorinated and polybrominated pollutants in mammals and human health

（一）. 2，4，5，2 '，5'-pentaCB（CB 101）和2，3，4，2 '，3'，6 '-hexaCB（CB 132）暴露后，羟基化和甲磺酰基化PCB在大鼠、小鼠、豚鼠和仓鼠体内的组织分布差异较大。全血强烈保留了CB 132的儿茶酚代谢产物。古恩大鼠（遗传性UGT 1缺陷）在暴露于Kanechlor 500后大量产生源自CB 110和CB 149的儿茶酚代谢物。（二）、2，4，2 '，5'-tetraBrB的代谢产物3 '-MeSO_2- 2，4，2'，5 '-tetraBrB在大鼠体内是CYP 2B_（1/2）的强诱导剂。与MeSO_2-PCBs不同，该代谢物不降低大鼠血清中甲状腺激素（T4）水平。（三）、鲸肉中的卤代污染物及其生物学效应：在鲸产品中检测到几种溴代化合物以及氯代化合物（PCB、DDTs和氯代烷）。小鼠暴露于鲸脂产品中的有机卤素污染物后，血清中的某些生化指标（谷丙转氨酶、淀粉酶和T4）发生了变化。此外，这些污染物暴露于培养的大鼠胚胎在器官形成过程中，在四害性观察到剂量依赖性的方式。（四）、采用负离子CI/GC/MS技术对人肝脏中的MeSO_2-PCBs进行了分析。CB 87、CB 101和CB 149的主要代谢产物为5 '-MeSO_2- 2，3，4，2'，3 '，6'-hexaCB（约占总MeSO_2-PCBs的60%），其次为3-或4-MeSO_2。

(1). Species difference in metabolism of PCBTissue distribution of hydroxylated and methylsulfonyl PCB were largely different among rats, mice, guinea pigs and hamsters after exposure to 2,4,5,2',5'-pentaCB (CB101) and 2,3,4,2',3',6'-hexaCB (CB132). Hamster blood strongly retained a catechol metabolite from CB132. Gunn rats, hereditarily UGT1s deficient, highly produced catechol metabolites derived from CB110 and CB149 after exposure to Kanechlor 500.(2). Metabolism of polybrominated biphenyl and enzyme induction3'-MeSO_2-2,4,2',5'-tetraBrB, a metabolite of 2,4,2',5'-tetraBrB, was found to be a potent inducer of CYP2B1/2 in rats. Unlike MeSO_2-PCBs, this metabolite showed no reduction of thyroid hormone (T4) level in rat serum.(3). Halogenated pollutants in whale meat and its biological effects.Several brominated compounds as well as chlorinated ones (PCB, DDTs and chlordanes) were detected in whale products. Exposure of mice to the organohalogen contaminants in blubber products resulted in changes of some biochemical parameters (GPT, amylase and T4) in serum. Also, these pollutants were exposed to cultured rat embryos during organogenesis, where the tetratogenicity was observed in a dose-dependent manner.(4). MeSO_2-PCBs in human liverHuman liver was analyzed for MeSO_2-PCBs by negative CI/GC/MS technique. A major component was 5'-MeSO_2-2,3,4,2',3',6'-hexaCB (about 60% of total MeSO_2-PCBs), followed by 3- or 4-MeSO_2 metabolites derived from CB87, CB101 and CB149.