BASIC RESEARCH FOR DEVELOPMENT OF LASER SPECKLE BLOOD VELOCIMETER USING A SELF-MIXING LASER DIODE

自混合激光二极管激光散斑血速仪研制的基础研究

• 批准号: 12680828
• 负责人: SHINOHARA Shigenobu
• 金额: $ 2.37万
• 依托单位: SHIZUOKA UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2000
• 资助国家: 日本
• 起止时间: 2000 至 2001
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12680828/
• 关键词: BLOOD VELOCIMETER; NON CONTACT; SELF-MIXING; LASER DIODE; SPECKLE; AUTO CORRELATION; CORRELATION TIME; SKTN PHANTOM; 平均周波数

(1) Blood Flow Measurement by Autocorrelation Function Method :The inverse of the correlation time calculated from the autocorrelation function of a speckle signal obtained from a self-mixing laser diode (SM-LD) shows a linear dependence on a blood flow velocity with a far smaller offset frequency.(2) Comparison of the SM-LD Speckle Blood Flow Velocimeter with Two Commercially Available Blood Flow Velocimeters :A time dependence of the mean frequency with an averaging time 2 seconds for a human finger which was measured by the SM-LD blood flow velocimeter showed a similar tendency to a time dependence of the blood flow velocity measured by a laser Doppler velocimeter. During the measurement the blood flow was changed in 3 phases by adjusting the pressure of the cuff wound around the upper arm. Furthermore, another time dependence of the mean frequency with an averaging time 0.02 seconds obtained by the SM-LD velocimeter had fairly good coincidence with a time dependence of the blood fl … More ow velocity obtained by an ultrasonic Doppler blood flow velocimeter, which shows repeated velocity peaks due to the heart beat.(3) Calibration of the SM-LD Speckle Blood Flow Velocimeter :An obtained slope parameter was 13 Hz/mm/s in a velocity range 40 mm/s to 130 mm/s. The 13Hz/mm/s was smaller than a slope parameter 22Hz/mm/s obtained for sheep total blood filled in a gutter of a rotating turn table. While the 13Hz/mm/s was nearly equal to 15Hz/mm/s obtained for the sheep total blood flowing through a silicon tube with an inner and external diameter 1 mm and 2mm, respectively.(4) Simulating Experiment Using a Skin Phantom and a Tube :From the experiment using both a skin phantom plate made of gelatin containing distributed and fixed total sheep blood and intralipid and a silicon vein tube, a measurable skin depth was confirmed less than 1mm and the measured velocity was assumed due to the blood flow in capillaries of the finger. Reduction of the artifact effect is one of future research subject. Less

(1)通过自相关函数方法测量血流：根据自混合激光二极管（SM-LD）获得的散斑信号的自相关函数计算的相关时间的倒数显示出对血流速度的线性依赖性，偏移频率小得多。(2)SM-LD斑点血流速度计与两种市售血流速度计的比较：由SM-LD血流速度计测量的平均时间为2秒的人手指的平均频率的时间依赖性显示出与由激光多普勒速度计测量的血流速度的时间依赖性相似的趋势。在测量过程中，通过调节上臂袖带的压力，使血流发生3个时相的变化，并得到了平均时间为0.02秒的平均频率的时间依赖关系，与血流的时间依赖关系有较好的一致性 ...更多信息 通过超声多普勒血流速度计获得的流速，其显示由于心跳而导致的重复速度峰值。(3)SM-LD斑点血流速度计的校准：在40 mm/s至130 mm/s的速度范围内，获得的斜率参数为13 Hz/mm/s。13 Hz/mm/s小于填充在旋转转台槽中的绵羊全血获得的斜率参数22 Hz/mm/s。而绵羊全血流经内径为1 mm和外径为2 mm的硅胶管时，所获得的13 Hz/mm/s与15 Hz/mm/s几乎相等。(4)使用皮肤体模和管的模拟实验：从使用由含有分布和固定的总羊血和胰岛素的明胶制成的皮肤体模板和硅静脉管的实验中，证实可测量的皮肤深度小于1 mm，并且假设测量的速度是由于手指毛细血管中的血流。减少伪影效应是未来的研究课题之一。少

项目成果

S.K.OZDEMIR, S.SHINOHARA, S.TAKAMIYA, H.YOSHIDA: "NON-INVASIVE BLOOD FLOW MEASUREMENT USING SPECKLE SIGNALS FROM A SELF-MIXING LASER DIODE: IN-VITRO AND IN-VIVO EXPERIMENTS"OPTICAL ENGINEERING. 39,9. 2574-2580 (2000)

S.K.OZDEMIR、S.SHINOHARA、S.TAKAMIYA、H.YOSHIDA：“使用自混合激光二极管散斑信号进行非侵入性血流测量：体外和体内实验”光学工程。

S.SHINOHARA, I.OHNO, S.K.OZDEMIR, H.YOSHIDA: "NON-CONTACT IN-VIVO MEASUREMENT OF TIME VARYING SKIN BLOOD FLOW USING SEMICONDUCTOR LASER SPECKLE VELOCIMETER"PROC. OF INTERMAC 2001 JOINT TECHNICAL CONFERENCE, SA1-6, Nov. 7. (2001)

S.Shinohara、I.OHNO、S.K.OZDEMIR、H.YOSHIDA：“使用半导体激光散斑测速仪对随时间变化的皮肤血流进行非接触式体内测量”过程。

大野功, 庭山雅嗣, 生熊紀昭, 吉田博文, 篠原茂信: "自己混合半導体レーザスペックルによる血流速度計測の特性解析-皮膚組織ファントム実験による検討-"2002年エム・イー学会講演論文集. (5月10日発表予定). (2002)

Isao Ohno、Masatsugu Niwayama、Noriaki Ikuma、Hirofumi Yoshida、Shigenobu Shinohara：“使用自混合半导体激光散斑的血流速度测量的特性分析 - 使用皮肤组织模型实验的研究 -”2002 EM 会议论文集（（预定于 2002 年）于 5 月 10 日公布）（2002 年）。

S.K.OZDEMIR, S.TAKAMIYA, S.SHINOHARA, H.YOSHIDA: "SELF-MIXING LASER SPECKLE VELOCIMETER FOR BLOOD FLOW MEASUREMENT"IEEE TRANSACTIONS ON INSTRUMENTATION AND MEASUREMENT. 49,5. 1029-1035 (2000)

S.K.OZDEMIR、S.TAKAMIYA、S.SHINOHARA、H.YOSHIDA：“用于血流测量的自混合激光散斑测速仪”IEEE 仪器和测量交易。

S.K.OZDEMIR, S.SHINOHARA, S.TAKAMIYA, H.YOSHIDA: "NON-INVASIVE BLOOD FLOW MEASUREMENT USING SPECKLE SIGNALS FROM A SELF-MIXING LASER DIODE : IN-VITRO AND IN-VIVO EXPERIMENTS'"OPTICAL ENGINEERING. 39, 9. 2574-2580 (2000)

S.K.OZDEMIR、S.SHINOHARA、S.TAKAMIYA、H.YOSHIDA：“使用自混合激光二极管散斑信号进行非侵入性血流测量：体外和体内实验”光学工程。