Research of the temporal discrimination learning and EEG pattern in rats.

本研究的目的是利用电生理活动来评估不同脑区在时间辨别学习中的作用。包括时间在内的时间辨别学习是行为最重要的性质之一。研究动物时间感知的方法主要有三种，即时间辨别或时间平分法、时间分化法（如DRL、DRLL）和峰间隔法（PI）。我进行了3个实验，分别是2秒和8秒的时间区分、4秒的DRLL计划和30秒的峰值间隔计划。我得到的结果是，所有的方法都可以达到学习的标准，没有任何问题。2003年4月，我在《日本生理心理学与心理生理学》上发表了一篇文章。脑电图反映了与某些时间决策过程相关的大脑活动。大脑对外部刺激反应的变化可以通过测量诱发电位来研究。对时间标准的判断等内部刺激会引起偶相关电位（ERP）。刺激起效的erp由P2、N2和p3样成分组成。在额皮质和海马CAI中一致观察到p3样成分。与简单的反应时间任务相比，在时间分辨任务中观察到更大的p3样成分振幅。在刺激偏移时，P2、N2和p3样成分被激发，同时刺激开始。刺激抵消时额叶皮层的p3样成分在时间分辨任务中比在简单反应时间任务中更大。我还计算了海马体功率谱。在听觉刺激开始时，海马波功率在时间辨别任务中比在时间控制任务中增加得更多。我在2002年的神经科学会议上发表了题为《大鼠脑电图上的定时行为和光驱动》的论文。我发表了一篇关于工作记忆和时间信息处理的论文。少

The purpose of this study is to evaluate the roles of various brain regions in temporal-discrimination learning by using electrophysiological activity. Temporal-discrimination learning which include in timing is one of the most important properties of behavior. There are three major methods to study time perception in animals, this is, temporal-discrimination or temporal-bisection procedure, temporal-differentiation procedure (e. g. DRL, DRLL), and peak-interval (PI) procedure. I had three experiments that were temporal-discrimination between 2-sec and 8-sec, DRLL 4 sec schedule, and peak-interval 30-sec procedure. I had the results that all method could reach the criterion in learning without any problem. I published an article in Japanese Physiological Psychology and Psychophysiology in April 2003.EEG is reflected by the brain activity associated with certain temporal decision processes. Changes in brain responsiveness to an external stimulus can be investigated by the measurement of … More evoked potentials. An internal stimulus such as the judgment of a temporal criterion will evoke an even-related potential (ERP). The stimulus onset ERPs consisted of P2, N2, and P3-like components. P3-like component was consistently observed for the frontal cortex and hippocampal CAI. Significantly greater amplitudes of the P3-like components was observed during the temporal-discrimination task when compared to the simple reaction-time task. At the stimulus offset, P2, N2, and P3-like components were elicited as well as the stimulus onset. P3-like component in the frontal cortex at the stimulus offset was larger for the temporal-discrimination task than for the simple reaction-time task. I also calculated hippocampal power spectra. The hippocampal theta power increased more in the temporal-discrimination task than in the temporal control task at the onset of the auditory stimuli. I presented at the neuroscience meeting in 2002 entitled timing behavior and photic driving on EEG in rats. I published a paper dealing with working memory and processing of temporal information. Less