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Brain electrical activity on temporal discrimination in rats.

脑电活动对大鼠时间辨别的影响。

基本信息

批准号：
16530471
负责人：
SAKATA Shogo
金额：
$ 2.44万
依托单位：
Hiroshima University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2004
资助国家：
日本
起止时间：
2004 至 2007
项目状态：
已结题

项目摘要

We studied the electrical activity of the brain on timing behavior in rats. This study was investigated for the function of the brain on the temporal discrimination task in rats. In this experimental study, animals were trained in operant chambers using the peak-interval (PI) 30-s procedure that included fixed interval (FI) 30-s trials and probe trials. The FI 30-s trials consisted of a food pellet reinforcement that presented by the first lever press response more than 30-s after the onset of tone stimulus, and the stimulus was terminated. The probe trials delivered no reinforcement with responses and tone stimulus lasted for 90-s. The 3-s bin of lever press responses on probe trials showed a clear peak point. This PI procedure is a useful procedure to investigate about timing in rats.The peak time corresponded to near the 30-s with reinforcement time. In the self-start group, the number of responses at the beginning of the trials exceeded that of the control group. But the peak point was the same as the autonomic start control group. The peak time corresponded to near the 30-s with reinforcement durations. The graph had a peak point that showed the peak of the regression curve fitting with the Poisson function. Then the electrodes were implanted in the rat brain. We measured the hippocampal electroencephalography (EEG) with performing PI procedure in rats. The electrodes were implanted in the sub-cortex brain areas. The EEG power of the hippocampus and striatum region showed hippocampal theta rhythm correlation with timing behavior patterns. These results suggest that the hippocampus and striatum oscillations are important with timing mechanism in the brain. The hippocampus and striatum may play a very important role to estimate the passage of the time in living animals.

我们研究了大鼠大脑的电活动对时间行为的影响。本研究探讨了大鼠在时间分辨任务中的脑功能。在本实验研究中，动物在手术室中使用峰值间隔(PI)30-S程序进行训练，其中包括固定间隔(FI)30-S试验和探头试验。FI 30-S试验包括：在纯音刺激开始后，第一个杠杆按压反应出现超过30-S的食物颗粒强化，刺激终止。探头试验没有提供任何反应和音调刺激，持续了90-S。在探头试验中，杠杆按压反应的3-S桶有一个明显的峰值。这个PI程序是研究大鼠计时的一个有用的程序，峰值时间对应于接近30-S的强化时间。在自我启动组中，试验开始时的回答次数超过了对照组。但峰值与自主神经启动对照组相同。随着加固时间的延长，高峰期对应于30-S附近。曲线图有一个峰值，该峰值用泊松函数拟合回归曲线的峰值。然后将电极植入大鼠的大脑。我们测量了实施PI手术的大鼠的海马脑电(EEG)。电极被植入大脑皮质下区域。海马区和纹状体区的脑电功率与计时行为模式呈海马theta节律相关。这些结果表明，海马体和纹状体的振荡在大脑中具有重要的计时机制。在活着的动物中，海马体和纹状体可能对估计时间的流逝起着非常重要的作用。