Testing Effects of Environmental Exposures on Subsequent Human Generations

测试环境暴露对人类后代的影响

• 批准号: DE220101226
• 负责人: Dr Gunn-Helen Moen
• 金额: $ 30.38万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Early Career Researcher Award
• 财政年份: 2022
• 资助国家: 澳大利亚
• 起止时间: 2022-03-01 至 2026-02-28
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DE220101226
• 关键词: Testing; Effects; Environmental; Exposures; Subsequent

This project aims to develop new statistical models to determine how environmental exposures in pregnancy, such as smoking, alcohol consumption and diet, can impact the first and second generations of children. The project will fill a void in unbiased tools to disentangle genetic and environmental components in the inheritance of complex traits, and will be the first to determine objectively if and how effects from environmental exposures can be inherited. Through international collaborations and advanced interdisciplinary approaches, this project will generate new knowledge in the emerging field of multigenerational inheritance to drive the future design of interventions and influence positive behaviours during pregnancy.

该项目旨在开发新的统计模型，以确定怀孕期间的环境暴露，如吸烟、饮酒和饮食，如何影响第一代和第二代儿童。该项目将填补无偏见工具的空白，以解开复杂性状遗传中的遗传和环境因素，并将首次客观地确定环境暴露的影响是否以及如何遗传。通过国际合作和先进的跨学科方法，该项目将在多代遗传的新兴领域产生新的知识，以推动未来干预措施的设计，并影响怀孕期间的积极行为。