Association of anti-oxidant vitamins and C-reactive protein with non-invasive brachial-ankle pulse wave velocity and ankle -brachial index in Japanese middle-aged male workers

日本中年男性工人抗氧化维生素和C反应蛋白与无创臂踝脉搏波速度和踝臂指数的关系

• 批准号: 13670360
• 负责人: OKAMURA Tomonori
• 金额: $ 1.34万
• 依托单位: SHIGA UNIVERSITY OF MEDICAL SCIENCE
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13670360/
• 关键词: C-reactive protein; brachial-ankle pulse wave velocity; alpha-tocopherol; folate; vitamin B12; drinking; smoking; ankle-brachial index; 高感度C反応性蛋白(hs-CRP); 容積脈波(PWV); アルコール(飲酒); BMI; 食生活; C反応性蛋白(CRP); 生活習慣

Pulse wave velocity (PWV) is an indicator of arterial stiffness, especially in aorta, and a marker for vascular damage. We examined the association of brachial-ankle PWV (baPWV) with serum alpha-tocopherol and C-reactive protein (CRP) levels in addition to the traditional risk factors. Study subjects comprised of 178 Japanese male workers aged 50-59 without past histories of cardiovascular diseases. The relation of baPWV with serum alpha-tocopherol and CRP levels were cross-sectionally analyzed after adjusting for other cardiovascular risk factors. Arithmetic mean of serum alpha-tocopherol was 38.9"mol/L and geometric mean of serum CRP was 0.47mg/L. Multiple linear regression analysis indicated that serum CRP levels were associated with the elevation of baPWV, in addition to age, systolic blood pressure and heart rate. However, serum alpha-tocopherol, serum lipids (triglyceride, low and high density lipoprotein cholesterol), fasting plasma glucose, body mass index, smoking and alcohol drinking did not significantly correlate to baPWV. Multivariate adjusted means of baPWV according to serum CRP quartile were 1431, 1436, 1507 and 1508 [cm/sec] (P=0.033). Serum CRP level might be an important marker for arterial stiffness in Japanese middle-aged males. However, the relation of alpha-tocopherol and other anti-oxidant vitamins to baPWV was not evident.

脉搏波传导速度（PWV）是反映动脉僵硬度的指标，特别是在主动脉中，也是血管损伤的标志。除了传统的危险因素外，我们还研究了臂踝PWV（baPWV）与血清α-生育酚和C-反应蛋白（CRP）水平的关系。研究对象包括178名日本男性工人，年龄在50-59岁之间，既往无心血管疾病史。校正其他心血管危险因素后，对baPWV与血清α-生育酚和CRP水平的关系进行横断面分析。血清α-生育酚算术平均值为38.9“mol/L，血清CRP几何平均值为0.47 mg/L。多元线性回归分析显示，除年龄、收缩压、心率外，血清CRP水平与baPWV升高相关。然而，血清α-生育酚、血脂（甘油三酯、低密度脂蛋白胆固醇和高密度脂蛋白胆固醇）、空腹血糖、体重指数、吸烟和饮酒与baPWV无显著相关性。根据血清CRP四分位数，baPWV的多变量校正平均值为1431、1436、1507和1508 [cm/sec]（P=0.033）。血清CRP水平可能是日本中年男性动脉硬化的一个重要指标。然而，α-生育酚和其他抗氧化维生素与baPWV的关系并不明显。

项目成果

Title of article; Non-invasive measurement of brachial-ankle pulse wave velocity associated with serum C-reactive protein but not with alpha-tocopherol in Japanese middle-aged male workers

文章标题；

• 发表时间: 2004
• 期刊: Hypertension Research Vol.27(3)(in press)
• 作者: Tomonori Okamura;Yuri Moriyama;Takashi Kadowaki;Hideyuki Kanda;Yoshikuni Kita;Hirotsugu Ueshima.
• 通讯作者: Hirotsugu Ueshima.

血中ホモシステイン、葉酸、ビタミンB12と動脈硬化の関連

血同型半胱氨酸、叶酸、维生素B12与动脉硬化的关系

• 发表时间: 2001
• 期刊: Vitamin Information Center News Letter 103
• 作者: Tomonori Okamura;Yuri Moriyama;Takashi Kadowaki;Hideyuki Kanda;Yoshikuni Kita;Hirotsugu Ueshima.;森山ゆり
• 通讯作者: 森山ゆり

森山ゆり, 岡村智教: "本邦における血中ホモシステインおよび関連ビタミン濃度を規定する生活習慣に関する検討"動脈硬化. 29. 228 (2003)

Yuri Moriyama、Tomonori Okamura：“日本决定血液同型半胱氨酸和相关维生素浓度的生活习惯研究”动脉硬化。

岡村智教: "アルコールと動脈硬化性疾患"動脈硬化予防. 1巻3号. 106-110 (2003)

Tomonori Okamura：“酒精与动脉硬化疾病”，《动脉硬化预防》，第 1 卷，第 3 期，106-110（2003 年）。

Moriyama Y, Okamura T, Kajinami K, et al.: "Effect of serum B vitamins on elevated plasma homocysteine levels associated with the mutation of methylenetetrafolate reductase gene in Japanese"Atherosclerosis. (in press). (2002)

Moriyama Y、Okamura T、Kajinami K 等人：“血清 B 族维生素对日本人与亚甲基四叶酸还原酶基因突变相关的血浆同型半胱氨酸水平升高的影响”动脉粥样硬化。