The development of lifestyle modification for cardiovascular risk factors based on their related genotypes in a Japanese general population.

根据日本普通人群的相关基因型对心血管危险因素的生活方式进行调整。

• 批准号: 16590500
• 负责人: OKAMURA Tomonori
• 金额: $ 2.24万
• 依托单位: SHIGA UNIVERSITY OF MEDICAL SCIENCE
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2004
• 资助国家: 日本
• 起止时间: 2004 至 2005
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-16590500/
• 关键词: ALDH2; CETP; α-adducin; angiotensinogen; HDL cholesterol; alcohol drinking; hypertension; salt intake; アセトアルデヒド脱水素酵素(ALDH2); コレステリルエステル転送蛋白(CETP); アンギオテンシノーゲン(AGT); Body mass index (BMI); 塩分摂取量

We examined the interaction between lifestyle and polymorphisms of salt-sensitive genes and the effect on hypertension in a Japanese population. Among 1,647 subjects not receiving antihypertensive medication, in a combined analysis of angiotensinogen (AGT) and adducin (ADD1) polymorphisms, double homozygosity of 235Thr or 460Trp was not associated with hypertension. A multiple logistic regression analysis showed that age, body mass index, alcohol consumption, family history of hypertension and combined AGT M235T Thr/Thr and ADD1 Trp/Trp polymorphisms were associated with hypertension. However, there was no interaction between eating salty food and combined AGT and ADD1 polymorphisms. Furthermore, eating salty food was not associated with hypertension in a multivariate analysis. Therefore, a combination of the AGT and ADD1 polymorphisms appears to have an association with hypertension. However, a simple questionnaire about salt intake was not sufficient to confirm the relation between salt intake and hypertension or salt-sensitive genes.Cholesteryl ester transfer protein (CETP) is a key enzyme in high-density lipoprotein (HDL) cholesterol metabolism. We also studied the association between CETP TaqIB polymorphism and the HDL cholesterol. The serum HDL cholesterol levels of female participants with the B2B2 genotype were significantly higher than those with other genotypes (p<0.001). Multiple regression analysis with covariates such as age, waist to hip (W/H) ratio, alcohol drinking, current smoking, non-HDL cholesterol, and logarithm of triglyceride revealed that the CETP TaqIB genotype was an independent determinant of HDL cholesterol levels. Subgroup analysis revealed that an interaction was observed between the CETP TaqIB polymorphism and alcohol consumption in the regulation of HDL cholesterol levels in men (p=0.049) and women (p=0.022).

我们研究了生活方式和盐敏感基因多态性之间的相互作用以及对日本人群高血压的影响。在1,647名未接受降压药物治疗的受试者中，在血管紧张素原（AGT）和内收蛋白（ADD 1）多态性的联合分析中，235 Thr或460 Trp的双纯合性与高血压无关。多因素Logistic回归分析显示年龄、体重指数、饮酒、高血压家族史以及AGT M235 T Thr/Thr和ADD 1 Trp/Trp基因多态性与高血压相关。然而，吃咸的食物和AGT和ADD 1基因多态性之间没有相互作用。此外，在多变量分析中，吃咸食物与高血压无关。因此，AGT和ADD 1多态性的组合似乎与高血压相关。然而，简单的盐摄入量调查问卷并不足以证实盐摄入量与高血压或盐敏感基因的关系。胆固醇酯转运蛋白（Cholesteryl ester transfer protein，CETP）是高密度脂蛋白（high density lipoprotein，HDL）胆固醇代谢的关键酶。我们还研究了CETP TaqIB多态性与HDL胆固醇的关系。女性B2 B2基因型者血清HDL胆固醇水平显著高于其他基因型者（p<0.001）。多元回归分析的协变量，如年龄，腰臀比（W/H），饮酒，目前吸烟，非高密度脂蛋白胆固醇，甘油三酯的对数显示，CETP TaqIB基因型是一个独立的决定因素高密度脂蛋白胆固醇水平。亚组分析显示，在男性（p=0.049）和女性（p=0.022）中，CETP TaqIB多态性和饮酒在调节HDL胆固醇水平方面存在相互作用。

项目成果

Epidemiologic aspects of ALDH2 genotypes and cardiovascular parameters. Comprehensive Handbook of Alcohol Related Pathology, Vol.2.(Preedy V and Watson R (eds).)

ALDH2 基因型和心血管参数的流行病学方面。

• 发表时间: 2005
• 作者: Yamada M;Honda S;Iwanaga M;Kondo H;Mine M;Yokota K;Shibata Y.;Okamura T.
• 通讯作者: Okamura T.

Combined analysis of polymorphisms in angiotensinogen and adducin genes and their effects on hypertension in a Japanese sample : The Shigaraki Study

日本样本中血管紧张素原和内收蛋白基因多态性的联合分析及其对高血压的影响：信乐研究

• 发表时间: 2005
• 期刊: Hypertension Research 28(8)
• 作者: Tamaki S;Okamura T;et al.
• 通讯作者: et al.

Preedy V and Watson R (eds). Epidemiologic aspects of ALDH2 genotypes and cardiovascular parameters. Comprehensive Handbook of Alcohol Related Pathloogy, Vol.2.

Preedy V 和 Watson R（编辑）。

• 发表时间: 2005
• 作者: Okamura T.

Epidemiologic aspects of ALDH2 genotypesand cardiovascular parameters.

ALDH2 基因型和心血管参数的流行病学方面。

• 发表时间: 2005
• 期刊: Comprehensive Handbook of Alcohol Related Pathology (Preedy V and Watson R eds.) Vol.2
• 作者: Kurimori S;Fukuda Y;et al.;吉田 稔 他;Okamura T
• 通讯作者: Okamura T

The association between high-density lipoprotein cholesterol level and cholesteryl ester transfer protein TaqIB gene polymorphism is influenced by alcohol drinking in a population-based sample

基于人群的样本中高密度脂蛋白胆固醇水平与胆固醇酯转移蛋白 TaqIB 基因多态性之间的关联受到饮酒的影响

• 发表时间: 2007
• 期刊: Atherosclerosis 191(1)
• 作者: Tsujita Y;et al.
• 通讯作者: et al.