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Studies on Biochemical Indicators of Dietary Intake

膳食摄入生化指标的研究

基本信息

批准号：
13670381
负责人：
DATE Chigusa
金额：
$ 2.24万
依托单位：
Mukogawa Women's University (2002-2003)Osaka City University (2001)
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2001
资助国家：
日本
起止时间：
2001 至 2003
项目状态：
已结题

项目摘要

We targeted 242 healthy residents(121 male and 121 female) of Nagano, Osaka, Tottori and Okinawa, ranging in age from 30 to 60 for our research. In order to assess 13 kinds of biochemical markers in blood, we obtained their two blood samples at a one-year interval. These biochemical markers were considered to show the individuals' dietary intake level. Furthermore, we conducted weighing record dietary survey with them for a total of 16 days, that is, four days each season during one year and computed the annual means of the nutrients in their dietary intake.We computed the Pearson correlation coefficient of the above-mentioned biochemical markers at a one-year interval. The correlation coefficients of vitamins were from 0.3 to 0.5, and those of cholesterol approximately 0.8. They were statistically significant. These results confirmed the high reproducibility of biochemical markers.In addition, we computed the correlation coefficients of dietary nutrient intakes and biochemical markers in blood. The correlation coefficients of Vitamin E,Vitamin B_6,Vitamin 6_<12>,folic acid and Vitamin C showed the range from 0.18 to 0.35.Furthermore, with respect to the correlation coefficients of dietary Vitamin C intake and Vitamin C concentration in blood, the females were found higher than the males.We hereby surmised that Vitamin C concentration in blood might have been reduced by smoking.We concluded that it would be highly possible to use these vitamins in blood as biochemical markers which would indicate dietary intake during a short term(about 2 weeks) or a long term (about 1 year).

我们选取长野、大阪、鸟取和冲绳的242名健康居民（男121名，女121名）进行研究，年龄在30 - 60岁之间。为了评估血液中的13种生化指标，我们每隔一年获得他们的两次血液样本。这些生化指标被认为显示了个体的饮食摄入水平。在此基础上，对其进行了为期16天的体重记录膳食调查，即一年中每个季节4天，计算其膳食摄入中营养素的年平均值。我们以一年为间隔计算上述生化指标的Pearson相关系数。维生素的相关系数在0.3 ~ 0.5之间，胆固醇的相关系数在0.8左右。它们在统计学上是显著的。这些结果证实了生化标记的高重复性。此外，我们计算了膳食营养素摄入量与血液生化指标的相关系数。维生素E、维生素B_6、维生素6_<12 bb_0、叶酸和维生素C的相关系数在0.18 ~ 0.35之间。此外，在膳食维生素C摄入量与血液中维生素C浓度的相关系数方面，女性高于男性。我们据此推测，血液中的维生素C浓度可能因吸烟而降低。我们的结论是，很有可能在血液中使用这些维生素作为生化标记，以表明短期（约2周）或长期（约1年）的饮食摄入量。