Studies on Biochemical Indicators of Dietary Intake

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We targeted 242 healthy residents(121 male and 121 female) of Nagano, Osaka, Tottori and Okinawa, ranging in age from 30 to 60 for our research. In order to assess 13 kinds of biochemical markers in blood, we obtained their two blood samples at a one-year interval. These biochemical markers were considered to show the individuals' dietary intake level. Furthermore, we conducted weighing record dietary survey with them for a total of 16 days, that is, four days each season during one year and computed the annual means of the nutrients in their dietary intake.We computed the Pearson correlation coefficient of the above-mentioned biochemical markers at a one-year interval. The correlation coefficients of vitamins were from 0.3 to 0.5, and those of cholesterol approximately 0.8. They were statistically significant. These results confirmed the high reproducibility of biochemical markers.In addition, we computed the correlation coefficients of dietary nutrient intakes and biochemical markers in blood. The correlation coefficients of Vitamin E,Vitamin B_6,Vitamin 6_<12>,folic acid and Vitamin C showed the range from 0.18 to 0.35.Furthermore, with respect to the correlation coefficients of dietary Vitamin C intake and Vitamin C concentration in blood, the females were found higher than the males.We hereby surmised that Vitamin C concentration in blood might have been reduced by smoking.We concluded that it would be highly possible to use these vitamins in blood as biochemical markers which would indicate dietary intake during a short term(about 2 weeks) or a long term (about 1 year).