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Efficacy of dietary guidance to reduce high blood cholesterol in city dwellers : A randomized controlled trial

膳食指导降低城市居民高血胆固醇的功效：一项随机对照试验

基本信息

批准号：
09670407
负责人：
DATE Chigusa
金额：
$ 1.98万
依托单位：
Osaka City University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1997
资助国家：
日本
起止时间：
1997 至 1998
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09670407/
关键词：
randomized controlled trial dietary guidance serum total cholesterol LDL cholesterol dietary fat dietary cholesterol

项目摘要

PurposeTo clarify the lowering effect of serum total cholesterol(TCH) through dietary guidance by randomized controlled trial(RTC) conducted with city dwellers.MethodIt was conducted with citizens in District A in Osaka City and District A-I in Osaka Prefecture. People who were encouraged by telephone or letter to participate in RTC are follows : those aged between 40 and 69, whose TCH and HDL-CH measured at the time of health check-ups 6 months prior to RCT were between 230 and 279 mg/dl, and below 90 mg/dl, respectively. The candidates had the nature of RCT and the dietary guidance method explained to them, and gave informed consent by document.The first baseline examination was implemented in District A in May, 1997 and in District A-I in June, 1998. The number of the examinees was 92, and after eliminating those whose TCH was below 230 mg/dl, the qualified ones numbered 56 in District A and 19 in DistrictA-I, totaling 75. They were divided into two groups by randomized allocation and designated as a intervention group(IG), and a control group(CG). Regarding each one of the former group, three by-monthly dietary guidance sessions took place with a special focus on fat intake. Six months after the first examination, the second one was conducted with both groups.ResultsThe IG and the CG numbered 38 and 37, respectively, It was found that there was no difference in age and the mean measurements of TCH and BMI as found in the first examination.As far as the IG was concerned, TCH went down to 231.9 mg/dl in the second examination from 256.5 mg/dl showed in the first. The CG showed 252.7 mg/dl in the second examination, down from 256.6 mg/dl in the first. The net reduction of TCH through dietary guidance proved to be 20.7 mg/dl.

目的通过对大坂市A区和大坂府A-I区的城市居民进行的随机对照试验（RTC），阐明通过饮食指导降低血清总胆固醇（TCH）的效果。通过电话或信件鼓励参加RTC的人如下：年龄在40 - 69岁之间，在RCT前6个月健康检查时测得的TCH和HDL-CH分别在230 - 279 mg/dl之间和90 mg/dl以下。对受试者进行RCT的性质和膳食指导方法的解释，并以书面形式给予知情同意，1997年5月在A区和1998年6月在A-I区进行了第一次基线检查。考生人数为92人，剔除TCH低于230 mg/dl的考生后，A区合格人数为56人，A-I区合格人数为19人，共计75人。将研究对象随机分为干预组（IG）和对照组（CG）。对于前一组的每一个人，每月进行三次饮食指导会议，特别关注脂肪摄入量。结果两组的IG和CG分别为38例和37例，年龄、TCH和BMI的平均测量值与第一次检查时无差异，IG和CG的平均测量值与第一次检查时无差异，而CG的平均测量值与第一次检查时无差异。TCH从第一次检查的256.5 mg/dl下降到第二次检查的231.9 mg/dl。第二次检查时CG显示为252.7 mg/dl，低于第一次检查时的256.6 mg/dl。通过饮食指导，TCH的净减少量为20.7毫克/分升。