The comparison of virus genome and immune reaction between asymptomatic carriers and chronic hepatitis patients infected with HBV.

点击翻译按钮获取中文摘要

Antigen presenting cells were induced from spleen cells of HBcAg transgenic mouse (Tg10c), or HBeAg transgenic mouse (Tg30e), and HBcAg transgenic mouse has the better ability to induce HBcAg specific antigen presenting activity, but lower ability to express HBeAg.Antibody production against HBcAg or or HbeAg was slightly low in Tg10c, and almost lost in Tg30e.20 asymptomatic HBV carrier patients (group A) who has no symptom and no elevation of liver function test and 25 HBV related chronic hepatitis patients (group B) were analyzed for virolo9ical profile and cYtokine production.Although few mutations were detected in group A patients, several mutations were found in group B patients. Lots of mutations were concentrated in the core region. However, chronic hepatitis B does not appear to be caused by a specific genomic mutation or an amino acid mutation.In the cytokine production assay, the average interleukin 2 levels were higher in group B patients than that in group A patients. Similarly, and IFNγ levels were higher in group B patients than that in group A patients.