QTc Dispersion, Cardiac Sympathetic Functionand Secretion of Leptin in Patients with Obstructive Sleep Apnea.
阻塞性睡眠呼吸暂停患者的 QTc 离散度、心脏交感功能和瘦素分泌。
基本信息
- 批准号:13670598
- 负责人:
- 金额:$ 2.18万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Scientific Research (C)
- 财政年份:2001
- 资助国家:日本
- 起止时间:2001 至 2002
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Hypoxemia increases corrected QT dispersion (QTcD), which is a strong risk factor for cardiovascular mortality. QTc dispersion during sleep in 48 consecutive OSAHS patients [mean age: 45.9, apnea & hypopnea index (AHI) :51.9/h, the percentage of time that arterial O2 saturation below 90% (SaO2<90%): 28.7%] during sleep decreased significantly after first night of nCPAP therapy (p<0.0001). Before tratment, the QTcD during sleep correlated with the AHI (p=0.009) and SaO2<90% time (p= ). The QTcD did not correlate with the washout rate of iodine-l23-metaiodobenzylguanidine (MIBG) cardiac imaging. Nocturnal QTcD is increased in OSAHS patients but is decreased by nCPAP therapy independently of cardiac sympathetic function.The first night of nCPAP treatment significantly decreased the plasma leptin levels (p<0.02) in 21 OSAHS patients with AHI 52.4/h. The magnitude of decreases in leptin levels in OSAHS patients after nCPAP treatment were significantly correlated with cardiac sympathetic fun … More ction as measured by MIBG scintigraphy before nCPAP treatment (p<0.03). Plasma leptin levels in OSAHS patients decreased significantly after the first night of nCPAP treatment. Enhanced cardiac sympathetic function in OSAHS patients may contribute to the leptin levels before nCPAP treatment and vice versa.In 40 obese men with OSAHS, AST and ALT levels were determined in the afternoon and the morning immediately after sleep, before and after nCPAP treatment. Aminotransferase levels were abnormal in 35% of patients. Before treatment, AST levels were higher in the morning than the previous afternoon (p=0.006). The increase in morning fasting AST and ALT levels improved with significance after the first night of nCPAP treatment (AST, P=0.0003; ALT, p=0.006) Improvement of AST and ALT levels was maintained after 1 and 6 months of nCPAP treatment. OSAHS had significant effects on liver function. nCPAP therapy should be considered as a new strategy for patients with obesity and aminotransferase abnormalities who have obstructive sleep apnea. Less
低氧血症可增加校正QT离散度(QTcD),这是心血管死亡的一个强风险因素。48例连续OSAHS患者[平均年龄45.9岁,呼吸暂停低通气指数(AHI)51.9/h,动脉血氧饱和度低于90%(SaO 2 <90%)的时间百分比28.7%]在nCPAP治疗第一晚后睡眠时QTc离散度显著降低(p<0.0001)。治疗前睡眠时QTcD与AHI(p=0.009)和SaO 2 <90%时间(p= 0.001)相关。QTcD与碘-123-间碘苄胍(MIBG)心脏显像的洗脱率无关。21例AHI为52.4/h的OSAHS患者经nCPAP治疗后第1夜血浆瘦素水平显著降低(P<0.02),但与心交感神经功能无关。nCPAP治疗后OSAHS患者瘦素水平下降的幅度与心脏交感神经功能显著相关。 ...更多信息 在nCPAP治疗前通过MIBG血管造影术测量的动脉压(p<0.03)。OSAHS患者经nCPAP治疗第一夜后血浆瘦素水平明显下降。在40例肥胖男性OSAHS患者中,分别于nCPAP治疗前、治疗后及治疗后的下午和清晨测定血清AST和ALT水平。35%的患者转氨酶水平异常。治疗前,上午的AST水平高于前一天下午(p=0.006)。在nCPAP治疗的第一个晚上后,早晨空腹AST和ALT水平的升高显著改善(AST,P=0.0003; ALT,p=0.006)。在nCPAP治疗1个月和6个月后,AST和ALT水平的改善得以维持。OSAHS对肝功能有明显影响。nCPAP治疗应被视为肥胖和转氨酶异常伴阻塞性睡眠呼吸暂停患者的新策略。少
项目成果
期刊论文数量(16)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
K Chin: "Plasma leptin levels and cardiac sympathetic function in patients with obstructive sleep apnoea-hypopnoea syndrome"Recent Res Devel Resp Critical Care Med. 1. 95-100 (2001)
K Chin:“阻塞性睡眠呼吸暂停低通气综合征患者的血浆瘦素水平和心脏交感功能”Recent Res Devel Resp Critical Care Med。
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
陳 和夫, 他: "睡眠時呼吸障害-6章,肥満と睡眠時呼吸障害"日本評論社. 195 (2002)
Kazuo Chen 等人:“睡眠呼吸障碍 - 第 6 章,肥胖和睡眠呼吸障碍”Nippon Hyoronsha 195 (2002)。
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
Chin K, et al.: "Effects of obstructive sleep apnea syndrome on serum aminotransferase levels in obese patients"American Journal of Medicine. 114. 370-376 (2003)
Chin K 等人:“阻塞性睡眠呼吸暂停综合征对肥胖患者血清转氨酶水平的影响”美国医学杂志。
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
Chin K.: "Obstructive sleep apnea-hypopnea syndrome and multiple risk factors for cerebrovascular and cardiovascular disease"Recent Research Development in Respiratory & Critical Care Medicine. 1. 95-100 (2001)
Chin K.:“阻塞性睡眠呼吸暂停低通气综合征和脑血管和心血管疾病的多种危险因素”呼吸系统的最新研究进展
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
陳 和夫, 他: "睡眠時呼吸障害-6章, 肥満と睡眠時呼吸障害"日本評論社. 195(93-100) (2002)
Kazuo Chen 等人:“睡眠呼吸障碍 - 第 6 章,肥胖和睡眠呼吸障碍”Nippon Hyoronsha 195(93-100) (2002)。
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
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- 通讯作者:
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CHIN Kazuo其他文献
CHIN Kazuo的其他文献
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{{ truncateString('CHIN Kazuo', 18)}}的其他基金
The development of methods to make changes in the property of induced pluripotent stem cells by the intermittent or sustained hypoxia.
通过间歇性或持续性缺氧改变诱导多能干细胞特性的方法的开发。
- 批准号:
23659109 - 财政年份:2011
- 资助金额:
$ 2.18万 - 项目类别:
Grant-in-Aid for Challenging Exploratory Research
Effects of obstructive sleep apnea with intermittent and sustained hypoxia on platelet aggregability and adipocyte.
间歇性和持续性缺氧的阻塞性睡眠呼吸暂停对血小板聚集性和脂肪细胞的影响。
- 批准号:
20590921 - 财政年份:2008
- 资助金额:
$ 2.18万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Clinical and Basic Study of Thioredoxin as a Oxidative Stress Marker in Patients with Obstructive Sleep Apnea
硫氧还蛋白作为阻塞性睡眠呼吸暂停患者氧化应激标志物的临床和基础研究
- 批准号:
18603003 - 财政年份:2006
- 资助金额:
$ 2.18万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Changes in coagulation and fibrinogenolysis (factor VII clotting activity and type 1 plasminogen activator inhibitor) in patients with obstructive sleep apnea syndrome following nasal continuous positive airway pressure therapy.
阻塞性睡眠呼吸暂停综合征患者经鼻持续气道正压通气治疗后凝血和纤维蛋白原溶解(VII 因子凝血活性和 1 型纤溶酶原激活剂抑制剂)的变化。
- 批准号:
09670608 - 财政年份:1997
- 资助金额:
$ 2.18万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
相似海外基金
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