Effects of obstructive sleep apnea with intermittent and sustained hypoxia on platelet aggregability and adipocyte.

点击翻译按钮获取中文摘要

We showed that platelet aggregability was increased in patients with moderate-to-severe obstructive sleep apnea (OSA) partly through an intermittent hypoxia and reoxygenation phenomenon, which is pathophysiologically characteristic of OSA. As the effects of the severity of OSA on platelet aggregability were stronger in patients with vascular risk factors, the co-existence of OSA should be examined for the treatment of patients with multiple risk factors. Continuous therapy with continuous positive airway pressure (CPAP) improved platelet aggregability at 90 days. Thus, one of the reasons for the increase in cardiovascular events in OSA could be increased platelet aggregability. Under the hypoxic conditions which were induced by our machine, intermittent hypoxia induced TNF-α、and sustained hypoxia induced hypoxia inducible factor-1 (HIF-1) in HeLa cells.