Proposal of the new concept, "Platelet VEGF"

提出新概念“血小板VEGF”

• 批准号: 13670659
• 负责人: HASHIGUCHI Teruto
• 金额: $ 0.77万
• 依托单位: Kagoshima University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13670659/
• 关键词: VEGF; platelet; Crow-Fukase syndrome; POEMS syndrome; transgenic mouse; megakaryocyte; atherosclerosis; diabetic retinopathy; VEGF; Crow-Fukase syndrome; 血小板; 内皮細胞; 血管新生; 動脈硬化; 血栓症

Vascular endothelial growth factor (VEGF) is an endothelial cell-specific potent mitogen that induces angiogenesis and microvascular hyperpermeability. Recently, megakaryocytes and platelets reportedly have contained VEGF in their cytoplasm. Furthermore, almost VEGF that detected in human serum has been derived from platelets. We present here the bio-activity of VEGF in platelets that enhances the endothelial cell proliferation. We also demonstrated that gelatinase A (matrix metalloproteinases-2) which is closely associated with vascular remodeling enhances VEGF levels released from platelets. We detected VEGF in the fibrin net of a thrombus and hypothesize that VEGF in platelets (platelet VEGF) and gelatinase A play an important role in angiogenesis and wound healing in conjunction with other platelet cytokines such as platelet-derived growth factor.

血管内皮生长因子（VEGF）是内皮细胞特异性的强效丝裂原，可诱导血管生成和微血管高通透性。最近，据报道，巨核细胞和血小板的细胞质中含有VEGF。此外，在人血清中检测到的VEGF几乎来源于血小板。我们在此提出了VEGF在血小板中的生物活性，增强内皮细胞的增殖。我们还证明了与血管重构密切相关的明胶酶A（基质金属蛋白酶-2）可以提高血小板中VEGF的释放水平。我们在血栓的纤维蛋白网中检测到VEGF，并假设血小板中的VEGF（血小板VEGF）和明胶酶a与其他血小板细胞因子（如血小板衍生生长因子）一起在血管生成和伤口愈合中发挥重要作用。

项目成果

Teruto Hashiguchi: "Highly concentrated vascular endothelial growth factor in platelets in Crow-Fukase syndrome"Muscle Nerve. 23・7. 1051-1056 (2000)

Teruto Hashiguchi：“Crow-Fukase 综合征中血小板中的高浓度血管内皮生长因子”肌肉神经 23・7（2000 年）。

Wataru Matsuyama: "Purified protein derivative of tuberculin upregulates the expression of vascular endothelial growth factor in T lymphocytes in vitro"Immunology. 106・1. 96-101 (2002)

Wataru Matsuyama：“结核菌素的纯化蛋白衍生物在体外上调 T 淋巴细胞中血管内皮生长因子的表达”免疫学 106・1（2002）。

Teruto Hashiguchi, Kimiyoshi Arimura, Kenji Matsumoto, Reika Otsuka, Osamu Watanabe, Manabu Jonosono, Yoshikazu Maruyama, Ikuro Maruyama, and Mitsuhiro Osame: "HIGHLY CONCENTRATED VASCULAR ENDOTHELIAL GROWTH FACTOR IN PLATELETS IN CROW-FUKASE SYNDROME"MUS

Teruto Hashiguchi、Kimiyoshi Arimura、Kenji Matsumoto、Reika Otsuka、Osamu Watanabe、Manabu Jonosono、Yoshikazu Maruyama、Ikuro Maruyama 和 Mitsuhiro Osame：“乌鸦-深濑综合征血小板中的高浓度血管内皮生长因子”MUS

Wataru Matsuyama: "Serum levels of vascular endothelial growth factor dependent on the stage progression of lung cancer"Cest. 118・4. 948-951 (2000)

Wataru Matsuyama：“血管内皮生长因子的血清水平取决于肺癌的阶段进展”Cest 948-951（2000）。

Koji Inoue: "Expression of vascular endothelial growth factor in pulmonary aspergilloma"Internal Medicine. 40・12. 1195-1199 (2001)

井上浩二：“肺曲霉瘤中血管内皮生长因子的表达”内科40・1199（2001）。