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Investigation of the unknown factor over stimulating the VEGF prodution in Crow-Fukase syndrome.

Crow-Fukase 综合征中过度刺激 VEGF 产生的未知因素的调查。

基本信息

批准号：
15590901
负责人：
HASHIGUCHI Teruto
金额：
$ 2.24万
依托单位：
Kagoshima University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2003
资助国家：
日本
起止时间：
2003 至 2004
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15590901/
关键词：
Crow-Fukase syndrome POEMS syndrome vascular endothelial growth factor VEGF platelet megakaryocyte embryonic lethality B cell platelet Crow-Fukase syndrome POEMS syndrome transgenic mouse megakaryocyte atherosclerosis diabetic

项目摘要

Vascular endothelial growth factor(VEGF) is an endothelial cell-specific potent mitogen that induces angiogenesis and microvascular hyperpermeability. Megakaryocytes and platelets are a very rich source of circulating VEGF. Platelet VEGF is bioactive as a direct angiogenic growth factor, and may play a very important role in wound healing and atherosclerosis (J Thromb Haemost.2003,(12):2589-93). In Crow-Fukase(POEMS) syndrome, platelet VEGF markedly elevated. We reported a case diagnosed as Crow-Fukase syndrome, in which the serial platelet count and VEGF concentration were determined before and during the state of disseminated intravascular coagulation(DIC). The serum VEGF concentration was noted to be gradually decreased prior to DIC, after which it abruptly decreased with a corresponding drop in platelet count upon the onset of DIC. The physiological effects of VEGF are viewed as one of the causative factors in DIC and its abrupt and excessive release may have caused the exacerbation of the patient's clinical symptoms(Tokashiki T et al. Intern Med. 2003,42(12):1240-3). The factors which stimulate the over-production of platelet VEGF in Crow-Fukase syndrome is still unknown. To investigate this unknown factor, we are planning to facilitate the proteomics technology in the next project.

血管内皮生长因子（VEGF）是一种内皮细胞特异性的有丝分裂原，可诱导血管生成和微血管通透性增高。巨核细胞和血小板是循环VEGF的非常丰富的来源。血小板VEGF作为直接的血管生成生长因子具有生物活性，并且可能在伤口愈合和动脉粥样硬化中起非常重要的作用（J Thromb Haemost.2003，（12）：2589-93）。Crow-peptide（POEMS）综合征患者血小板VEGF水平明显升高。我们报告一例诊断为Crow-Dopase综合征的患者，在弥散性血管内凝血（DIC）前和期间连续测定血小板计数和VEGF浓度。DIC前血清VEGF浓度逐渐降低，DIC后血清VEGF浓度突然降低，血小板计数也相应下降。VEGF的生理作用被认为是DIC的致病因素之一，并且其突然和过度释放可能导致患者临床症状的恶化（Tokashiki T等，Intern Med.2003，42（12）：1240-3）。在Crow-peptide综合征中刺激血小板VEGF过度产生的因素仍然未知。为了研究这个未知因素，我们计划在下一个项目中促进蛋白质组学技术。

项目成果

期刊论文数量（26）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Highly accumulated platelet vascular endothelial growth factor in coagulant thrombotic region

DOI：
10.1046/j.1538-7836.2003.00475.x
发表时间：
2003-12-01
期刊：
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
影响因子：
10.4
作者：
Arisato, T;Hashiguchi, T;Maruyama, I
通讯作者：
Maruyama, I

Takayo Arisato: "Highly accumulated platelet vascular endothelial growth factor in coagulant thrombotic region."J Thromb Haemost. 1・12. 2589-2593 (2003)

Takayo Arisato：“凝血性血栓区域中高度积累的血小板血管内皮生长因子。”J Thromb Haemost 1・12 2589-2593（2003）。

DOI：
发表时间：
期刊：
影响因子：
0
作者：
通讯作者：

The agonist of the protease-activated receptor-1(PAR) but not PAR3 mimics thrombin-induced vascular endothelial growth factor release in human smooth muscle cells.

蛋白酶激活受体 1 (PAR) 而非 PAR3 的激动剂可模拟凝血酶诱导的人类平滑肌细胞中血管内皮生长因子的释放。

DOI：
发表时间：
2003
期刊：
Cell Mol Life Sci. 60(8)
影响因子：
0
作者：
Arisato T;Sarker KP;Kawahara K;Nakata M;Hashiguchi T;Osame M;Kitajima I;Maruyama I.
通讯作者：
Maruyama I.

Takashi Tokashiki: "Predictive value of serial platelet count and VEGF determination for the management of DIC in the Crow-Fukase(POEMS) syndrome"Intern Med. 42・12. 1240-1243 (2003)

Takashi Tokashiki：“连续血小板计数和 VEGF 测定对 Crow-Fukase（POEMS）综合征 DIC 治疗的预测价值” Intern Med 42・12（2003）。