Investigation of the unknown factor over stimulating the VEGF prodution in Crow-Fukase syndrome.

血管内皮生长因子(VEGF)是一种内皮细胞特异性的有丝分裂原，可诱导血管生成和微血管高通透性。巨核细胞和血小板是循环血管内皮生长因子的一个非常丰富的来源。作为一种直接的血管生成生长因子，血小板血管内皮生长因子具有生物活性，在伤口愈合和动脉粥样硬化中可能起着非常重要的作用(血栓血肿杂志，2003，(12)：2589-93)。在乌鸦-福凯斯综合征(POEMS)中，血小板血管内皮生长因子显著升高。本文报告一例Crow-Fukase综合征患者，在弥散性血管内凝血(DIC)前和DIC期间分别测定了血小板计数和血管内皮细胞生长因子(VEGF)浓度。血清中的血管内皮生长因子浓度在DIC前逐渐降低，之后突然下降，在DIC开始时伴随着血小板计数的相应下降。血管内皮生长因子的生理效应被认为是DIC的致病因素之一，它的突然和过度释放可能导致患者临床症状的恶化(Tokashiki T等人)。实习医生。2003，42(12)：1240-3)。在Crow-Fukase综合征中刺激血小板血管内皮生长因子过度产生的因素尚不清楚。为了研究这一未知因素，我们计划在下一个项目中促进蛋白质组学技术的发展。

Vascular endothelial growth factor(VEGF) is an endothelial cell-specific potent mitogen that induces angiogenesis and microvascular hyperpermeability. Megakaryocytes and platelets are a very rich source of circulating VEGF. Platelet VEGF is bioactive as a direct angiogenic growth factor, and may play a very important role in wound healing and atherosclerosis (J Thromb Haemost.2003,(12):2589-93). In Crow-Fukase(POEMS) syndrome, platelet VEGF markedly elevated. We reported a case diagnosed as Crow-Fukase syndrome, in which the serial platelet count and VEGF concentration were determined before and during the state of disseminated intravascular coagulation(DIC). The serum VEGF concentration was noted to be gradually decreased prior to DIC, after which it abruptly decreased with a corresponding drop in platelet count upon the onset of DIC. The physiological effects of VEGF are viewed as one of the causative factors in DIC and its abrupt and excessive release may have caused the exacerbation of the patient's clinical symptoms(Tokashiki T et al. Intern Med. 2003,42(12):1240-3). The factors which stimulate the over-production of platelet VEGF in Crow-Fukase syndrome is still unknown. To investigate this unknown factor, we are planning to facilitate the proteomics technology in the next project.