Induction of immunological tolerance for hen's egg allergy

鸡蛋过敏的免疫耐受诱导

• 批准号: 13670849
• 负责人: URISU Atsuo
• 金额: $ 1.6万
• 依托单位: Fujita Health University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2003
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13670849/
• 关键词: Egg allergy; Oral immunological tolerance; Heated and ovomucoid-depleted egg white; Specific IgE antibody; Specific IgG4 antibody; Oral desensitization therapy; Induction therapy of remission; 特異的IgG4抗体; オボムコイド; アウトグロー; IL-4; INF-γ; Th1・Th2

1,Clarification of mechanism of food allergy; 1) Characterization of IgE-epitopes of buckwheat flour.2)We demonstrated the cross-reactivity between antigens from tomato-fruit and Japanese cedar pollen.2.Development of hypoallergenic egg white; We confirmed the safety in long term oral administration of heated and ovormucoid-deleted egg white.3,Clarification of mechanism of outgrow of egg allergyNormalization of balance between Th1Th2 cytokine productions is involved in the outgrowing of egg allergy.4.Development of induction of remission in egg allergy ;Egg-allergic children were orally administered four pieces of cookie including heated and ovomucoid-depleted egg white equivalent to one egg for 14 to 28 days. The long-term oral administration induced negative oral challenge results in approximately 50% of children with egg allergy. Egg-white-specific IgG4 was suggested to be involved in the remission.

1.食物过敏机理的阐明：1）荞麦粉IgE抗原表位的鉴定; 2）番茄和柳杉花粉抗原的交叉反应性研究; 2.低致敏性蛋清白色的研制;我们证实了长期口服加热和去除卵粘蛋白的蛋清的安全性。3，鸡蛋变态反应过度发生机制的阐明Th 1 Th 2细胞因子平衡的正常化参与了鸡蛋变态反应过度发生。4.鸡蛋变态反应诱导缓解的研究进展;鸡蛋过敏的儿童口服四片饼干，包括加热和卵类粘蛋白耗尽的鸡蛋白色相当于一个鸡蛋，持续14至28天。长期口服给药引起的阴性口服激发导致约50%的儿童鸡蛋过敏。提示蛋清特异性IgG 4参与了缓解。

项目成果

宇野須厚雄, 川口博史, 各務美智子 他: "食物アレルギーの診断と治療における修飾食物抗原の応用"日小児アレルギー会誌. 16・2. 154-158 (2002)

Atsuo Unosu、Hiroshi Kawaguchi、Michiko Kagami 等：“改良食物抗原在食物过敏诊断和治疗中的应用”日本小儿过敏学会杂志 16・2（2002 年）。

徳田玲子, 宇理須厚雄 他: "加熱脱オボムコイド卵白を用いた寛解導入の試み"日小児アレルギー会誌. 18(1). 75-79 (2004)

Reiko Tokuda、Atsuo Urisu 等人：“尝试使用热耗尽的卵类粘蛋白诱导缓解”，《日本儿科过敏杂志》18(1) (2004)。

Kondo Y, Tokuda R, Urisu A, et al.: "Assessment of cross-reactivity between Japanese cedar (Cryptomeria japonica) pollen and tomato fruit extracts by RAST inhibition and immunoblot inhibition"Clin Exp Allergy. 32. 590-594 (2002)

Kondo Y、Tokuda R、Urisu A 等人：“通过 RAST 抑制和免疫印迹抑制评估日本雪松 (Cryptomeria japonica) 花粉和番茄果实提取物之间的交叉反应性”Clin Exp Allergy。

徳田玲子, 宇理須厚雄: "アレルギー疾患と食物"アレルギーの臨床. 22(11). 865-870 (2002)

Reiko Tokuda，Atsuo Urisu：“过敏性疾病和食物”临床过敏22（11）。

宇理須厚雄: "食物とアトピー性皮膚炎"小児内科. 35(4). 667-671 (2003)

Atsuo Urisu：“食物和特应性皮炎”小儿内科 35（4）667-671（2003）。