Development of food antigens for oral immunotherapy to hen's egg allergy

开发用于鸡蛋过敏口服免疫疗法的食物抗原

• 批准号: 19591268
• 负责人: URISU Atsuo
• 金额: $ 2.83万
• 依托单位: Fujita Health University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19591268/
• 关键词: 小児免疫; アレルギー; 膠原病学; 鶏卵アレルギー; 免疫療法; オボムコイド減量加熱全卵; TGF-βmRNA; IFN-γ; IP-10mRNA; IL-4も、mRNA; Th1; Th2; IL-4; IL-13; Eotaxin; SOCS-3; 経口免疫寛容; CISH

The efficiency of oral immunotherapy for food allergy has been already approved in many articles. The IT is associated in varying degrees with side effects such as urticaria, abdominal pain and anaphylaxis. We have made heated and ovomucoid-reduced whole egg, upgraded hypoallergenic food antigens for IT. The IT using this egg antigen has been proved the safety and efficiency in this study. The response of Th2 cytokine (IL4) as well as Th1 cytokine (IFN-gamma) in peripheral mononuclear cells was decreased after the stimulation by egg white antigen in vitro.

口服免疫疗法对食物过敏的有效性已经在许多文章中得到证实。IT在不同程度上与副作用相关，如荨麻疹、腹痛和过敏反应。本研究制备了加热去卵类粘蛋白的全蛋，升级了低致敏性食物抗原用于免疫注射，证明了该抗原用于免疫注射的安全性和有效性。体外实验表明，受鸡卵白色抗原刺激后，外周血单个核细胞对Th 2型细胞因子（IL 4）和Th 1型细胞因子（IFN-γ）的反应性降低。

项目成果

Utility of ovomucoid-specific IgE concentrations in predicting symptomatic egg allergy

• DOI: 10.1016/j.jaci.2008.06.016
• 发表时间: 2008-09-01
• 期刊: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
• 影响因子: 14.2
• 作者: Ando, Hitoshi;Moverare, Robert;Urisu, Atsuo
• 通讯作者: Urisu, Atsuo

Long-term oral immunotherapy by hypoallergenic heated and ovomucoid-reduced egg white in subjects with hen's egg allergy.

对鸡蛋过敏的受试者进行低过敏性加热和减少卵类粘蛋白的蛋清的长期口服免疫治疗。

• 发表时间: 2009
• 作者: Urisu A;Naruse N;Ahn J;Komatsubara R;Hirata N;Yukawa M;Suzuki S;Ando H;Kondo Y;Tsuge I;Yamada K;Kobayashi S;Kimura
• 通讯作者: Kimura

オボムコイド減量加熱全卵を含む全粥のアレルゲン性の評価

减少卵类粘蛋白加热全蛋全麦粥的致敏性评价

• 发表时间: 2008
• 作者: 山田一恵;平田典子;小松原亮;湯川牧子;各務美智子;鈴木聖子;安在根;近藤康人;柘植郁哉;木村守;宇理須厚雄
• 通讯作者: 宇理須厚雄

やさしい食物アレルギーの自己管理(改訂版)

简易食物过敏自我管理（修订版）

• 发表时间: 2009
• 作者: Suzuki M;et al.;宇理須厚雄(分担)
• 通讯作者: 宇理須厚雄(分担)

Specific detection of buckwheat residues in processed foods by polymerase chain reaction

聚合酶链反应特异性检测加工食品中的荞麦残留

• 发表时间: 2008
• 期刊: Biosci Biotechnol Biochem 72
• 作者: Yamakawa H;Akiyama H;Endo Y;Miyatake K;Sakai S;Kondo K;Toyoda M;Urisu A;Teshima R
• 通讯作者: Teshima R