Quantification of the heterogeneity of cerebral blood flow SPECT in the patients with vascular dementia.

血管性痴呆患者脑血流 SPECT 异质性的量化。

• 批准号: 13670934
• 负责人: HASHIKAWA Kazuo
• 金额: $ 2.24万
• 依托单位: KYOTO UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13670934/
• 关键词: vascular dementia; CBF SPECT; fractal dimension; Alzheimer's disease; 脳血栓性痴呆; 能血流SPECT

The heterogeneous distribution of CBF is one of the characteristic findings in SPECT for the vasucular dementia. However, no objective method to evaluate the heterogeneity has been established. In this study, we applied three-dimensional fractal analysis (3D-FA) to CBF SPECT images as a method for assessing the heterogeneity of the CBF distribution in MID. At first, we investigated 18 patients with MID and 18 age-matched controls. CBF SPECT images were obtained with ^<99m>Tc-HMPAO. On the reconstructed images, we obtained a linear regression equation between the cut-off values (from 35 to 50 %) and the number of voxels with a radioactivity exceeding the cut-off value transformed into natural logarithms, and then calculated the fractal dimension(FD) as the slope of the regression line thus obtained. The Mini-Mental State Examination (MMSE) was used to evaluate cognitive function. The FD was significantly greater in the MID group than in the control group (p < 0.0001). A significant negative correlation was observed between the FD and the MMSE score in the MID group (r = 0.871, p < 0.0001). In the second, we compared with the FDs of the patients with Alzheimer's disease(AD) and those of MID. The FDs of both groups were lower significantly than that of control subjects. The ratio of two FDs (FD of the anterior area and the FD of the posterior area: A/P ratio) was greater than 1 in the AD and lower 1 in the MID. The FD in the MID was siginificantly lower than that in the AD (P<0.001).These results suggested that the fractal dimension of CBF SPECT is useful in the quantitative evaluation of dementia in both the AD and the MID, and the A/P ratio of FD may be applied in differential diagnosis of dementia.

脑血流分布不均是血管性痴呆SPECT的特征性表现之一。然而，目前还没有建立评价非均质性的客观方法。在本研究中，我们将三维分形分析(3D-FA)应用于脑血流SPECT图像，作为一种评估脑血流分布在MID中的异质性的方法。首先，我们调查了18例MID患者和18名年龄匹配的对照组。~(99)m&GT；~(99)T-HMPAO脑血流SPECT扫描。在重建的图像上，我们得到了截止值(从35%到50%)与放射性超过截止值的体素数目之间的线性回归方程，并将其转换为自然对数，然后计算分维(FD)作为由此得到的回归线的斜率。采用简易智力状态检查(MMSE)评定认知功能。MID组FD明显大于对照组(P&lt；0.0001)。MID组FD与MMSE评分呈显著负相关(r=0.871，p&lt；0.0001)。在第二个实验中，我们比较了阿尔茨海默病(AD)患者和MID患者的FDs。两组患者的FDs均显著低于对照组。AD组两个FD值(前区FD与后区FD：A/P比值)大于1，中部小于1。MID组FD显著低于AD组(P&lt；0.001)，提示脑血流SPECT分维可用于AD和MID痴呆的定量评估，FD的A/P比值可用于痴呆的鉴别诊断。

项目成果

Yoshikawa T: "Quantification of the hetreogeneity of cerebral blood flow in vascular dementia"Journal of Neurology. 250. 194-200 (2002)

Yoshikawa T：“血管性痴呆中脑血流异质性的量化”神经病学杂志。

Yoshikawa T.: "Statistical image analysis of cerebral blood flow in vascular dementia with small vessel disease."Journal of Nuclear Medicine. (accepted).

Yoshikawa T.：“血管性痴呆伴小血管疾病的脑血流统计图像分析。”核医学杂志。

Murase K: "Reproducibility of the brain perfusion index for measuring cerebral blood flow using technetium-99mc ompounds"Eur J Nucl Med. 28・11. 1640-1648 (2001)

Murase K：“使用锝-99mc化合物测量脑血流量的脑灌注指数的再现性”Eur J Nucl Med 28・11 1640-1648（2001）。

Yoshikawa T.: "Quantification of the heterogeneity of cerebral blood flow in vascular dementia"Journal of Neurology. 250. 194-200 (2003)

Yoshikawa T.：“血管性痴呆中脑血流异质性的量化”神经病学杂志。

Yoshikawa T: "Quantification of the heterogeneity of cerebral blood flow in vascular dementia"Journal of Neurology. 250. 194-200 (2003)

Yoshikawa T：“血管性痴呆中脑血流异质性的量化”神经病学杂志。