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Remission of Graves' Hyperthyroidism and CTLA-4-Gene

Remission of Graves' Hyperthyroidism and CTLA-4-Gene
Graves 甲状腺功能亢进症和 CTLA-4 基因的缓解
批准号:
13671159
负责人:
TAKASU Nobuyuki
金额:
$2.24万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2001
资助国家:
日本
项目状态:
已结题
起止时间:
2001 至 2002

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中文摘要
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英文摘要
We studied whether a patient with Graves' disease will go into remission during antithyroid drug (ATD) treatment. Remission of Graves' hyperthyroidism is predicted by a smooth decrease in TSH receptor antibody (TRAb) during ATD treatment. Cytotoxic T cell lymphocyte-associated molecule-4 (CTLA-4) may play an important role in the development of Graves' hyperthyroidism and in its remission. We studied A/G polymorphism at position 49 in exon 1 of the CTLA-gene in Japanese Graves' patients. We revealed the association of CTLA-4 polymorphism with remission of Graves' hyperthyroidism.
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会议论文
Takasu N, et al.: "Remission of Graves' hyperthyroidism predicted by smooth decreases of thyroid-stimulating antibody and thyrotropin-binding inhibitory immunoglobulin during antithyroid drug treatment"Thyroid. 10(10). 891-896 (2001)
Takasu N 等人:“在抗甲状腺药物治疗期间,通过促甲状腺刺激抗体和促甲状腺素结合抑制性免疫球蛋白的平稳下降来预测格雷夫斯甲状腺功能亢进症的缓解”甲状腺。
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通讯作者:
Miyagi J, Takasu N et al.: "Detection of Epstein-Barr virus and human T-cell lymphotropic virus type 1 in malignant nodal lymphoma, studied in Okinawa, a subtropical area in Japan"Int J Hematol. 75(1). 78-84 (2002)
Miyagi J、Takasu N 等人:“在日本亚热带地区冲绳岛进行的恶性结节淋巴瘤中 Epstein-Barr 病毒和人 T 细胞嗜淋巴细胞病毒 1 型的检测”Int J Hematol。
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Ohshiro Y, Takasu N, et al.: "Sequence analysis of the pro-opiomelanocortin (POMC) gene in obese/diabetic Japanese"Int J Obes Relat Metab Disord. 26(5). 730-731 (2002)
Ohshiro Y、Takasu N 等人:“肥胖/糖尿病日本人中阿片黑皮质素原 (POMC) 基因的序列分析”Int J Obes Relat Metab Disord。
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通讯作者:
Sugimoto J, Matsuura N, Kinjo Y, Takasu N, Oda T, Jinno Y: "Transcriptionally active HERV-K genes: identification, isolation, and chromosomal mapping"Geonomics. 72. 137-144 (2001)
Sugimoto J、Matsuura N、Kinjo Y、Takasu N、Oda T、Jinno Y:“转录活性 HERV-K 基因:鉴定、分离和染色体作图”基因组学。
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59
    Development of highly sensitive assay for TSH receptor antibody (TRAb) ; simultaneous measurements of TSAb, TSBAb, and TBII
    • 批准号:
      16590911
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.3万
    • 财政年份:
      2004
    • 负责人:
      TAKASU Nobuyuki
    • 依托单位:
    Graves' & Hashimoto's diseases and apoptosis
    • 批准号:
      08671175
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $1.47万
    • 财政年份:
      1996
    • 负责人:
      TAKASU Nobuyuki
    • 依托单位:
    Molecular mechanisms of the developments of Graves' disease and diabetes mellitus ; O_2 production-DNA damage and their signal transductions
    Signal transduction systems for thyroid cell proliferation and differentiation and their abnormalities in Graves' thyroid cells
    • 批准号:
      62570509
    • 项目类别:
      Grant-in-Aid for General Scientific Research (C)
    • 资助金额:
      $0.32万
    • 财政年份:
      1987
    • 负责人:
      TAKASU Nobuyuki
    • 依托单位:
    海外基金