Remission of Graves' Hyperthyroidism and CTLA-4-Gene

Graves 甲状腺功能亢进症和 CTLA-4 基因的缓解

• 批准号: 13671159
• 负责人: TAKASU Nobuyuki
• 金额: $ 2.24万
• 依托单位: University of the Ryukyus
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13671159/
• 关键词: Graves' disease; Hyperthyroidism; Remission; CTLA-4; TSAb (thyroid stimulating Ab); TRAb (TSH receptor Ab); CTLA-4遺伝子多型; 放射線療法; 遺伝子異常; 高感度TSAb; CTLA-4遺伝子多形

We studied whether a patient with Graves' disease will go into remission during antithyroid drug (ATD) treatment. Remission of Graves' hyperthyroidism is predicted by a smooth decrease in TSH receptor antibody (TRAb) during ATD treatment. Cytotoxic T cell lymphocyte-associated molecule-4 (CTLA-4) may play an important role in the development of Graves' hyperthyroidism and in its remission. We studied A/G polymorphism at position 49 in exon 1 of the CTLA-gene in Japanese Graves' patients. We revealed the association of CTLA-4 polymorphism with remission of Graves' hyperthyroidism.

我们研究了Graves病患者在抗甲状腺药物（ATD）治疗期间是否会缓解。ATD治疗期间TSH受体抗体（TRAb）的平稳下降可预测Graves甲亢的缓解。细胞毒性T细胞淋巴细胞相关分子-4（CTLA-4）可能在Graves甲亢的发生和缓解中起重要作用。我们研究了日本Graves病患者CTLA基因外显子1第49位的A/G多态性。我们揭示了CTLA-4基因多态性与Graves甲亢缓解的关系。

项目成果

Takasu N, et al.: "Remission of Graves' hyperthyroidism predicted by smooth decreases of thyroid-stimulating antibody and thyrotropin-binding inhibitory immunoglobulin during antithyroid drug treatment"Thyroid. 10(10). 891-896 (2001)

Takasu N 等人：“在抗甲状腺药物治疗期间，通过促甲状腺刺激抗体和促甲状腺素结合抑制性免疫球蛋白的平稳下降来预测格雷夫斯甲状腺功能亢进症的缓解”甲状腺。

Miyagi J, Takasu N et al.: "Detection of Epstein-Barr virus and human T-cell lymphotropic virus type 1 in malignant nodal lymphoma, studied in Okinawa, a subtropical area in Japan"Int J Hematol. 75(1). 78-84 (2002)

Miyagi J、Takasu N 等人：“在日本亚热带地区冲绳岛进行的恶性结节淋巴瘤中 Epstein-Barr 病毒和人 T 细胞嗜淋巴细胞病毒 1 型的检测”Int J Hematol。

Ohshiro Y, Takasu N, et al.: "Sequence analysis of the pro-opiomelanocortin (POMC) gene in obese/diabetic Japanese"Int J Obes Relat Metab Disord. 26(5). 730-731 (2002)

Ohshiro Y、Takasu N 等人：“肥胖/糖尿病日本人中阿片黑皮质素原 (POMC) 基因的序列分析”Int J Obes Relat Metab Disord。

Sugimoto J, Matsuura N, Kinjo Y, Takasu N, Oda T, Jinno Y: "Transcriptionally active HERV-K genes: identification, isolation, and chromosomal mapping"Geonomics. 72. 137-144 (2001)

Sugimoto J、Matsuura N、Kinjo Y、Takasu N、Oda T、Jinno Y：“转录活性 HERV-K 基因：鉴定、分离和染色体作图”基因组学。

Yamakawa K, Kitamura K, Nonoguchi H, Takasu N, Miller RT, Tomita K: "Galpha13 induces preproET-1 gene expression via JNK"Hypertens Res. 25. 427-432 (2002)

Yamakawa K、Kitamura K、Nonoguchi H、Takasu N、Miller RT、Tomita K：“Galpha13 通过 JNK 诱导 preproET-1 基因表达”Hypertens Res。