The Withdrawal of Immunosuppressive Regimen by CD15s monitoring

在ABO血型不合的肾移植中，我们经历了导致移植物丢失的超急性排斥反应。在此期间，我们观察到CD15s抗原迅速升高，并出现两个高峰。双色流式细胞仪分析表明，该峰为CD10Ab染色的活化浆细胞。不进行脾切除被认为会激活受者脾中的记忆B淋巴细胞。我们在动物实验中得到了类似的结果。撤除免疫抑制后，CD15s高表达，肌酐升高。

In ABO incompatible renal transplantation, we experienced hyper acute rejection leading to graft loss. During this period, we observed the rapid elevation of CD15s Antigen with two high peaks. Double color flow cytometric analysis demonstrated that this high peak was activated plasma cells stained by CD10Ab. No performance of splenectomy was believed to activate memory B lymphocytes in recipient's spleen. We obtained the similar result in animal experiments. High expression of CD15s was observed with senu creatinine elevation after withdrawal of Immunosuppression.