The Withdrawal of Immunosuppressive Regimen by CD15s monitoring

通过 CD15 监测取消免疫抑制方案

• 批准号: 13671258
• 负责人: ISHIDA Hideki
• 金额: $ 1.86万
• 依托单位: Tokyo Women's Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13671258/
• 关键词: CD15s; Immunosuppressive Regimen; Rejection; withdrawal; ステロイド; 寛容状態; 免疫抑制剤の投与中止; イヌの動物実験; ヒトの応用

In ABO incompatible renal transplantation, we experienced hyper acute rejection leading to graft loss. During this period, we observed the rapid elevation of CD15s Antigen with two high peaks. Double color flow cytometric analysis demonstrated that this high peak was activated plasma cells stained by CD10Ab. No performance of splenectomy was believed to activate memory B lymphocytes in recipient's spleen. We obtained the similar result in animal experiments. High expression of CD15s was observed with senu creatinine elevation after withdrawal of Immunosuppression.

在ABO血型不合的肾移植中，我们经历了导致移植物丢失的超急性排斥反应。在此期间，我们观察到CD15s抗原迅速升高，并出现两个高峰。双色流式细胞仪分析表明，该峰为CD10Ab染色的活化浆细胞。不进行脾切除被认为会激活受者脾中的记忆B淋巴细胞。我们在动物实验中得到了类似的结果。撤除免疫抑制后，CD15s高表达，肌酐升高。

项目成果

Hideki ISHIDA: "Mycophenolate mofetil suppresses the production of anti-blood type antibodies after renal Tx across the ABO blood barrier"Transplantation. 74(8). 1187-1189 (2002)

Hideki ISHIDA：“吗替麦考酚酯抑制肾 Tx 跨越 ABO 血屏障后抗血型抗体的产生”移植。

Hideki Ishida, et al.: "CD15s monitoring as a means to select anti-rejection therapy in patients with rejection after renal transplantation"Transplantation. 69(10). 2208-2211 (2000)

Hideki Ishida 等人：“CD15s 监测作为肾移植后排斥反应患者选择抗排斥治疗的手段”移植。

ISHIDA H et al.: "The evaluation of graft irradiation as a method of preventing hemolysis after ABO-mismatched renal transplantation"Transpl Int. 15(8). 421-424 (2002)

ISHIDA H 等人：“移植物辐射作为预防 ABO 不匹配肾移植后溶血的方法的评估”Transpl Int。

ISHIDA H et al.: "Mycophenolate mofetil suppresses the production of anti-blood type anitbodies after renal transplantation across the abo blood barrier"Transplantation. 74(8). 1187-1189 (2002)

ISHIDA H 等人：“吗替麦考酚酯跨越 abo 血屏障抑制肾移植后抗血型抗体的产生”移植。

石田英樹 ら: "腎移植後拒絶反応の診断と治療における末梢血リンパ球CD15s抗原検出の有用性について"今日の移植. 12(5). 518-524 (1999)

Hideki Ishida 等人：“外周血淋巴细胞 CD15s 抗原检测在肾移植后排斥反应的诊断和治疗中的作用”，《今日移植》12(5) (1999)。