Molecular targetting therapy based on regulation of HER2 protein in advanced gastro-intestinal cancers

基于HER2蛋白调控的晚期胃肠癌分子靶向治疗

• 批准号: 13671313
• 负责人: INOMATA Masafumi
• 金额: $ 2.24万
• 依托单位: 大分医科大学
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2003
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13671313/
• 关键词: Gastric Cancer; Peritoneal Dissemination; Molecular Targetting Therapy; HER2; Murine Metastatic Model; 大腸癌

In this study, we have clarified the possibility of clinical application of a biotherapy based on regulation of HER2 protein in patients with gastro-intestinal cancer.(A)Retrospective clinico-pathological study :Overexpression of HER2 protein was associated with histologic type and liver metastasis, and was a prognostic factor in patients with Well-differentiated gastric cancer.(B)In vitro study :Cell growth of gastric cancer cell line, NCI-N87, expressing HER2 protein, was supressed by anti-HER2 antibody.(C)In vivo study :Tumor growth of NCI-N87 in subcutaneous inplantation was supressed by anti-HER2 antibody. These results suggested that A new therapy using a monoclonal antibody against HER2 protein was a potential candidate for a strategy of recurrence of well-differentiated gastric cancer, and its application could be decided by examining the status of HER2 expression of resected primary tumor.

在这项研究中，我们阐明了一种基于HER2蛋白调节的生物疗法在胃肠道肿瘤患者中临床应用的可能性。(A)回顾性临床病理研究：HER2蛋白过表达与组织学类型和肝转移有关，是高分化胃癌患者的预后因素。(B)体外研究：抗HER2抗体可抑制表达HER2蛋白的胃癌细胞株NCI-N87的细胞生长。(C)体内研究：抗her2抗体可抑制NCI-N87皮下植入的肿瘤生长。这些结果表明，使用针对HER2蛋白的单克隆抗体治疗高分化胃癌是一种潜在的复发策略，可以通过检测切除的原发肿瘤中HER2的表达状况来决定其应用。

项目成果

猪股雅史: "大腸癌リンパ節微小転移-予後因子としての臨床的意義-"G.I.Research. 11(3). 27-32 (2003)

Masashi Inomata：“结肠癌淋巴结微转移 - 作为预后因素的临床意义 -”G.I.Research 11(3) (2003)。

Yasuda K, Inomala M, Fujii K, Shiraishi N, Adachi Y, Kitano S: "Superficially spreading cancer of the stomach."Ann Surg Oncol. 9(2). 192-196 (2002)

Yasuda K、Inomala M、Fujii K、Shiraishi N、Adachi Y、Kitano S：“胃癌表面扩散。”Ann Surg Oncol。

Inomata M, Shiroshita H, Ishikawa K, Kitano S: "Clinicopathologic characteristics of early-stage mucinous gastric carcinoma."J Clin Gastroenterol. (in press). (2004)

Inomata M、Shiroshita H、Ishikawa K、Kitano S：“早期粘液性胃癌的临床病理特征。”J Clin Gastroenterol。