Predictive Factors of Hematogeneous metastasis in colon cancer

结肠癌血行转移的预测因素

• 批准号: 13671307
• 负责人: KITAMURA Kaoru
• 金额: $ 2.24万
• 依托单位: KYUSHU UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13671307/
• 关键词: Colon cancer; Hematogeneous metastasis; Predictive factor; neovascularity; CD150; 臨床病理学的因子

Background Incidence of colon cancer has been increasing rapidly for latest few years. Hematogeneous metastasis, for example liver metastasis, which is most important for determining prognosis of colon cancer, is plurally controlled by complicated mechanism of neovascularization. Clinical significance of overexpression of CD105 for evaluating of neovascularity has been reported since CD105 has specificity for new-born vessels.Materials and methods Degree of neovascularization was examined using paraffin blocked specimens from 115 colon cancers. (1) Overexpression of Protein level and mRNA of the VEGF was investigated. (2) Clinicopathological factors were examined according to overexpression of CD34 and CD105, which were devided into two groups, high MVD and low MVD. Results (1) (1) The incidence of lymphnode metastasis, livermetastasis and overexpression of VEGF were all significantly higher in high MVD group than in low MVD group. Protein level of VEGF had accordance to the mRNA leve: Seventy percent of VEGF positive patients were also positive for mRNA expression, while only 14.3% was positive in VEGF negative patients (1) (2) Elderly patients with colon cancer is known to have a relatively slow disease progression. The rate of overexpression of VEGF was significantly lower in elderly patient group (75 years or more) than in patients less than 75. However, there was no relationship between VEGF overexpression and age, and elderly patient group had better prognosis in VRGF positive population.(2) There is a significance correlation between the overexpression of CD34 and CD105 and liver metastasis. Five-year survival of patients with high density of CD105 was significant poorer than those with low density.

背景近年来结肠癌的发病率呈快速上升趋势。血行转移，如肝转移，是决定结肠癌预后的最重要因素，它受复杂的血管生成机制的多重控制。由于CD 105对新生血管具有特异性，因此CD 105过表达对评价新生血管的临床意义已有报道。(1)检测VEGF的蛋白水平和mRNA水平。(2)根据CD34、CD105的过度表达情况，将其分为高MVD组和低MVD组。结果（1）（1）高MVD组淋巴结转移、肝转移及VEGF过表达的发生率均显著高于低MVD组。VEGF蛋白表达与mRNA表达水平一致：VEGF阳性者70%同时表达mRNA，而VEGF阴性者仅14.3%表达mRNA（1）（2）老年结肠癌患者病情进展相对缓慢。老年组（75岁或以上）VEGF过表达率显著低于小于75岁的患者。而VEGF过表达与年龄无关，VRGF阳性人群中老年组预后较好。(2)CD34、CD105的过度表达与肝转移有显著相关性。CD105高密度组5年生存率明显低于低密度组。

项目成果

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Kinoshita J., Kitamura K., Tanaka S, et al.: "Clinical significance of PEA3 in human breast cancer"Surgery. 131(1). S222-225 (2002)

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