Expression of basic transcription regulatory element binding protein 2 (BTEB2) in human cerebral aneurysms

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Introduction: Smemb, which is known increase in synthetic smooth muscle cells (SMCs). The induction of the gene for Smemb is regulated by basic transcription regulatory element binding protein 2 (BTEB2). In the current study we investigated the expression of BTEB2 in the aneurysm to determine its role in aneurysmail development and in protection against wall rupture.Methods: Non-ruptured aneurysms (n=15) and ruptured aneurysms (n=12) were obtained at surgery or autopsy. Five control arteries were obtained at autopsy. The spesimens were stained immunohistochemically with antibodies to a-smooth muscle actin, macrophages and BTEB2.Results: In control cerebral arteries, SMCs in the media and macrophages in the adventitia were negative for BTEB2. In 7 of 9 non-ruptured aneurysms larger than 10 mm, but not in any of the small non-ruptured aneurysms, macrophages and SMCs in the luminal layer were positive for BTEB2. And in thrombus of non-ruptured giant aneurysms, SMCs migrated and macrophages were strongly positive for BTEB2. With the exception of a few large or giant aneurysms, in ruptured aneurysms, macrophages and SMCs in the luminal layer were negative for BTEB2.Conclusion: In our study, BTEB2-positive macrophages and SMCs were present in the luminal layer of larger and giant non-ruptured aneurysms. This suggests that BTEB2 expression in the aneurysmal wall is related to aneurismal growth and may against rupture.