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Analysis of the neural circuit related to sensory discrimination based on multi-dipole estimation with high temporal resolution

基于高时间分辨率多偶极子估计的感觉辨别相关神经回路分析

基本信息

批准号：
13671452
负责人：
KIKUCHI Yoshiaki
金额：
$ 2.05万
依托单位：
Tokyo Metropolitan University of Health Sciences
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2001
资助国家：
日本
起止时间：
2001 至 2002
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13671452/
关键词：
magnetoencephalography (MEG)multi-dipole hippocampus P3 working memory 弁別処理機構

项目摘要

Although new imaging methods for measuring regional cerebral blood flow and metabolism such as PET and fMRI provide a detailed anatomical picture of the brain regions that are active during an sensory discrimination process, these methods fail to reveal the time course of the active regions with sufficiently high temporal resolution. On the other hand, the time course of brain activity patterns can be measured at the millisecond level of resolution through recordings of the neuromagnetic fields that are generated by active populations of nerve cells. Furthermore, recently developed whole-cortex MEG systems enabled us to measure all the brain areas at a time, without repositioning to record each area. The purpose of the present study was to construct the system for semi-automatically estimating multiple dipoles with sufficiently high temporal resolution. Furthermore, the temporal structure of the neural activity related to sensory discrimination was investigated by using the analyzing s … More ystem.The algorithm for multi-dipole estimation is based on the following three basic points: 1) In selection of the pair of the inward maximum and the outward maximum, the most neighboring pair in one hemisphere is to be selected as the first step for estimation. 2) Estimation errors are less than 10%, 15% and 20% for 4, 3 and 2 dipoles respectively. 3) Multi-dipole estimation is carried out based on spatio-temporal continuity and stability of the neuronal activities.By using the system, the following neuronal activities were observed related to sensory discrimination: 1) activity in its modality-specific area. 2) the areas related to attention such as prefrontal area, cingulate gyrus, and so on. 3) the areas related to memory such as dorsolateral prefrontal cortex, hippocampus, parietal association cortex and temporal association cortex. These activities were estimated following the above order during the beginning, and in parallel after. These brain areas may construct the working memory system required for sensory discrimination. Less

尽管用于测量局部脑血流和代谢的新成像方法（例如 PET 和 fMRI）提供了感觉辨别过程中活跃的大脑区域的详细解剖图，但这些方法无法以足够高的时间分辨率揭示活跃区域的时间过程。另一方面，通过记录活跃的神经细胞群产生的神经磁场，可以以毫秒级的分辨率测量大脑活动模式的时间进程。此外，最近开发的全皮质脑磁图系统使我们能够一次测量所有大脑区域，而无需重新定位来记录每个区域。本研究的目的是构建具有足够高时间分辨率的半自动估计多个偶极子的系统。此外，利用分析系统研究了与感觉辨别相关的神经活动的时间结构。多偶极子估计算法基于以下三个基本点：1）在选择向内最大值和向外最大值对时，选择一个半球中最邻近的对作为估计的第一步。 2) 对于 4、3 和 2 个偶极子，估计误差分别小于 10%、15% 和 20%。 3）基于神经元活动的时空连续性和稳定性进行多偶极估计。通过使用该系统，观察到与感觉辨别相关的以下神经元活动：1）其模态特定区域的活动。 2）与注意力相关的区域，如前额叶区、扣带回等。 3）背外侧前额叶皮层、海马、顶叶联合皮层、颞叶联合皮层等与记忆相关的区域。这些活动在开始时按照上述顺序进行估计，之后并行进行。这些大脑区域可以构建感觉辨别所需的工作记忆系统。较少的